THE RADIOSENSITIZATION ACTIVITIES OF NITROTRIAZOLE DERIVATIVES AND QUINOXALINE di-N-OXIDES

Tang Lixia; Li Xinyuan; Shen Xun; Zhang Wensheng; Wu Yanfen; Li Wuling

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THE RADIOSENSITIZATION ACTIVITIES OF NITROTRIAZOLE DERIVATIVES AND QUINOXALINE di-N-OXIDES

更新时间：2023-04-23

- THE RADIOSENSITIZATION ACTIVITIES OF NITROTRIAZOLE DERIVATIVES AND QUINOXALINE di-N-OXIDES
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 1, Pages: 20-24(1997)
- 作者机构：
  
  1.中国科学院生物物理研究所　北京　100101
  2.北京医科大学药学院　北京　100083
- 作者简介：
- 基金信息：
- DOI：
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Tang Lixia, Li Xinyuan, Shen Xun, et al. THE RADIOSENSITIZATION ACTIVITIES OF NITROTRIAZOLE DERIVATIVES AND QUINOXALINE di-N-OXIDES. [J]. Journal of Radiation Research and Radiation Processing 15(1):20-24(1997)
DOI：

Tang Lixia, Li Xinyuan, Shen Xun, et al. THE RADIOSENSITIZATION ACTIVITIES OF NITROTRIAZOLE DERIVATIVES AND QUINOXALINE di-N-OXIDES. [J]. Journal of Radiation Research and Radiation Processing 15(1):20-24(1997) DOI：

摘要

为了提高射线对肿瘤组织中乏氧细胞的杀伤作用，同时又使周围正常组织不发生严重损伤，用HeLa-S 3细胞进行离体试验研究了硝基三唑衍生物及喹喔啉衍生物对肿瘤细胞的辐射增敏作用。结果表明，具异羟肟酸侧链的硝基三唑化合物和具甲酰羟胺侧链的喹喔啉双-N-氧化物对乏氧细胞具有较好的辐射增敏作用，且有氧毒性不大。此外，这两个化合物的水溶性也很好。

Abstract

The radiosensitization activities of nitrotriazole and quinoxalin derivatives, 2100-H, QN-2012 and QN-2013 for hypoxic cells were studied in vitro using HeLa-S 3 cell line. It was determined that the sensitivity enhancement ratio of the nitrotriazole 2100-H and the quinoxalines, QN-2012 and QN-2013, at concentration of 1 mmol/L were 1.4,1.76 and 1.79 respectively. The aerobic cytotoxicities of 2100-H and QN-2013 are much less than that of misonidazole. It seems that these two compounds may be two promising radiosensitizers for hypoxic cells.

关键词

硝基三唑类化合物喹喔啉双-N-氧化物辐射增敏

Keywords

3-nitro-124-triazolesQuinoxaline di-N-oxidesRadiosensitizationCytotoxicity

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Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Science

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（北京协和医学院中国医学科学院放射医学研究所）

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