PULSE RADIOLYSIS STUDIES OF THE INTERACTION OF HYDROXYCINNAMIC ACID DERIVATIVES WITH OXIDIZING OH ADDUCTS OF DNA

Jiang Yue; Yao Side; Lin Nianyun

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PULSE RADIOLYSIS STUDIES OF THE INTERACTION OF HYDROXYCINNAMIC ACID DERIVATIVES WITH OXIDIZING OH ADDUCTS OF DNA

更新时间：2023-04-23

- PULSE RADIOLYSIS STUDIES OF THE INTERACTION OF HYDROXYCINNAMIC ACID DERIVATIVES WITH OXIDIZING OH ADDUCTS OF DNA
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 2, Pages: 127-128(1997)
- 作者机构：
  
  1.中国科学院辐射化学开放研究实验室　中国科学院上海原子核研究所　上海　201800
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Jiang Yue, Yao Side, Lin Nianyun. PULSE RADIOLYSIS STUDIES OF THE INTERACTION OF HYDROXYCINNAMIC ACID DERIVATIVES WITH OXIDIZING OH ADDUCTS OF DNA. [J]. Journal of Radiation Research and Radiation Processing 15(2):127-128(1997)
DOI：

Jiang Yue, Yao Side, Lin Nianyun. PULSE RADIOLYSIS STUDIES OF THE INTERACTION OF HYDROXYCINNAMIC ACID DERIVATIVES WITH OXIDIZING OH ADDUCTS OF DNA. [J]. Journal of Radiation Research and Radiation Processing 15(2):127-128(1997) DOI：

摘要

氧自由基由于具有极其活泼的化学活性和致癌、致心血管疾病、感染及促进衰老等作用而引起人们的广泛关注。而羟自由基氧化性最强、毒性最大、其对DNA的损伤更加引入注目，它能引起DNA一系列的损伤，包括链的断裂，碱基的损伤，DNA与蛋白质交联等。抑制羟基自由基对细胞损伤有两个途径：（1）在羟基自由基与细胞作用之前就被清除；（2）快速修复羟基加成产物。后一种途径对细胞损伤保护常常起主导作用，这是由于药物在细胞体内含量特别低的缘故。

Abstract

Using a pulse radiolytic technique,it has been demonstrated that the interaction of oxidizing OH adducts of DNA with hydroxycinnamic acid derivatives proceeds via an electron transfer process with rate constant of (5~7)×10,8,dm,3, mol,-1, s,-1,. Besides, the rate for fast repair of OH adducts of dAMP and DNA (ssDNA anddsDNA) are slower than the corresponding rate for the rest OH adducts of DNA constituents. The slower rate for oxidizing OH adduct of dAMP and DNA has indicated that repair of oxidizing OH adduct of dAMP may be the rate determining process during the interaction of hydroxycinnamic acid derivatives with OH adduct of DNA containing the varieties of OH adducts of DNA constituents.

关键词

脉冲辐解DNA羟基加成产物修复损伤

Keywords

Pulse radiolysisOH adducts of DNARepair damage

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