THE RADIOSENSITIZING EFFECT OF HPD (HEMOTOPORPHYRIN DERIVATIVE) ON THE BREAST CANCER MA 737 OF MICE UNDER IRRADIATION OF 8 MEV <italic style="font-style: italic">β</italic> RAY

Wang Shun Bao; Wang Jheng; Shen Yu; Gu Xian Zhi

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THE RADIOSENSITIZING EFFECT OF HPD (HEMOTOPORPHYRIN DERIVATIVE) ON THE BREAST CANCER MA 737 OF MICE UNDER IRRADIATION OF 8 MEV β RAY

更新时间：2023-04-26

- THE RADIOSENSITIZING EFFECT OF HPD (HEMOTOPORPHYRIN DERIVATIVE) ON THE BREAST CANCER MA 737 OF MICE UNDER IRRADIATION OF 8 MEV β RAY
- Journal of Radiation Research and Radiation Processing Vol. 5, Issue 4, Pages: 57-59(1987)
- 作者机构：
  
  1.中国医学科学院肿瘤医院
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Wang Shun Bao, Wang Jheng, Shen Yu, et al. THE RADIOSENSITIZING EFFECT OF HPD (HEMOTOPORPHYRIN DERIVATIVE) ON THE BREAST CANCER MA 737 OF MICE UNDER IRRADIATION OF 8 MEV β RAY. [J]. Journal of Radiation Research and Radiation Processing 5(4):57-59(1987)
DOI：

Wang Shun Bao, Wang Jheng, Shen Yu, et al. THE RADIOSENSITIZING EFFECT OF HPD (HEMOTOPORPHYRIN DERIVATIVE) ON THE BREAST CANCER MA 737 OF MICE UNDER IRRADIATION OF 8 MEV β RAY. [J]. Journal of Radiation Research and Radiation Processing 5(4):57-59(1987) DOI：

摘要

实验用纯系津白2号雌鼠，自发可移植性乳腺癌MA 737，腹腔内注射血卟啉衍生物（HPD），2～3 mg，20～30 mg/kg，100～150 mg/kg，注射4～8小时后进行照射，照射用8 MeV ,β,线，剂量分组为5、7、12、15、20 Gy。照后逐日测量肿瘤的三径。测定结果用计算机程序进行分析。根据计算结果绘制剂量效应曲线。并由此曲线计算出增敏比（Sensitizer enhancement ratio）SER。,实验结果表明：腔腹内注射小剂量HPD（2～3 mg/kg）后增敏比为1.2，中剂量20～30 mg/kg时，增敏效果并不增加，大剂量100～150 mg/kg时增敏作用反而不如小剂量时好。提示血卟啉的放射增敏作用在小剂量时为好，为临床使用小剂量血卟啉增敏时多次用药及减少正常组织损伤提供了实验依据。

Abstract

The transplantable spontaneous tumors MA 737 of JB,2,female mice were used, using take the tumor regrowth deley as the endpoint. The mice were injected HPD i.p. THe doses of HPD were 2-3 mg/kg, 20—30 mg/kg, 100—150 mg/kg respectively.,Irradiations of 8 Mev β-ray generated from a linear accelerator were performed 4-8 hours after a single i. p. injection of HPD. The doses for irradiation were 5, 7, 12, 15, 20 Gy respectively. The results were analysed using a set of computer program.,After the administration of 2-3 mg/kg of HPD, the sensitizing enhancement ratio was 1.2, Middle dose of 20-30 mg/kg, no higher effect was found. While the large dose of 100—150 mg/kg was used, the effect was even lower.

关键词

放射增敏血卟啉光敏剂

Keywords

RadiosensitizationHematoporphyrin derivativePhotosensitizing agents

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Shanghai Institute of Radiation Medicine, Fudan University

(School of Public Health, University of South China,,)

1 (School of Radiological Medicine and Protection of Soochow University,,)

2 (School of Public Health of Soochow University,,)

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THE RADIOSENSITIZING EFFECT OF HPD (HEMOTOPORPHYRIN DERIVATIVE) ON THE BREAST CANCER MA 737 OF MICE UNDER IRRADIATION OF 8 MEV β RAY

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摘要

Abstract

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