RESEARCH ON TIME AND DOSE EFFECTS OF <italic style="font-style: italic">γ</italic>-INDUCED PROGRAMMED CELL DEATH

Tong Xi; Dong Yan; Zhang Shuangxi; Sun Zhixian

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RESEARCH ON TIME AND DOSE EFFECTS OF γ-INDUCED PROGRAMMED CELL DEATH

更新时间：2023-04-26

- RESEARCH ON TIME AND DOSE EFFECTS OF γ-INDUCED PROGRAMMED CELL DEATH
- Journal of Radiation Research and Radiation Processing Vol. 14, Issue 2, Pages: 111-115(1996)
- 作者机构：
  
  1.军事医学科学院放射医学研究所，北京 100850
  1.军事医学科学院基础医学研究所
- 作者简介：
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Tong Xi, Dong Yan, Zhang Shuangxi, et al. RESEARCH ON TIME AND DOSE EFFECTS OF γ-INDUCED PROGRAMMED CELL DEATH. [J]. Journal of Radiation Research and Radiation Processing 14(2):111-115(1996)
DOI：

Tong Xi, Dong Yan, Zhang Shuangxi, et al. RESEARCH ON TIME AND DOSE EFFECTS OF γ-INDUCED PROGRAMMED CELL DEATH. [J]. Journal of Radiation Research and Radiation Processing 14(2):111-115(1996) DOI：

摘要

通过对辐射所致程序性细胞死亡（PCD）的研究，揭示了射线诱发小鼠胸腺细胞PCD生成的时间及剂量效应规律，采用不同的检测PCD方法（DNA片段分析法及流式细胞术），比较了不同组织的辐射敏感性差异。结果表明：照射后4～6 h诱发胸腺细胞PCD生成最多。不同剂量照射，照后6 h取胸腺，发现20Gy时胸腺细胞PCD生成最多。脾、胸腺对辐射敏感，小剂量（1 Gy）即可检测到PCD形成；而心脏、大脑、肾对射线不敏感，照射10 Gy以上时，才能检测到PCD。

Abstract

Time courses and dose responses of γ-induced programmed cell death (PCD) in murine thymocytes after in vivo irradiation were studied, two methods (analysis of DNA fragmentation and flow cytometry) to determine PCD were implemented. The radiation sensitivity of different tissues was compared. It could be observed that the peak incidence of PCD occurred in thymocytes 4~6 h after irradiation. On the basis of this result, 6 h after irradiation was chosen for the determination of the dose response. The dose responses for thymocytes reached a plateau after dose of 20 Gy. Spleen and thymus, the radiosensitive organs, after 1 Gy γ-irradiatiom PCD could be detected,while the heart, brain and kidney, the non radiosensitive organs, PCD could only be detected after doses of 10 Gy and above.

关键词

程序性细胞死亡辐射时间及剂量效应辐射敏感性

Keywords

Programmed cell deathRadiationTime and dose effectSensitivity of radiation

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RESEARCH ON TIME AND DOSE EFFECTS OF γ-INDUCED PROGRAMMED CELL DEATH

DOI：

摘要

Abstract

关键词

Keywords

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