GROWTH INHIBITION OF MELANOMA <italic style="font-style: italic">IN VIVO</italic> BY COMBINING ONCOSTATIN M GENE TRANSFECTION WITH LOCALIZED RADIATION: A GENE—RADIOTHERAPY STRATEGY FOR TUMOR

Lü Xing; XING Ruiyun; PEI Xuetao; LU Ping; SUN Zhixian; WU Zuze

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GROWTH INHIBITION OF MELANOMA IN VIVO BY COMBINING ONCOSTATIN M GENE TRANSFECTION WITH LOCALIZED RADIATION: A GENE—RADIOTHERAPY STRATEGY FOR TUMOR

研究论文 | 更新时间：2023-04-26

- GROWTH INHIBITION OF MELANOMA IN VIVO BY COMBINING ONCOSTATIN M GENE TRANSFECTION WITH LOCALIZED RADIATION: A GENE—RADIOTHERAPY STRATEGY FOR TUMOR
- 辐射研究与辐射工艺学报 Vol. 19, Issue 2, Pages: 127-132(2001)
- 作者机构：
  
  1.军事医学科学院放射医学研究所北京 100850
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Lü Xing, XING Ruiyun, PEI Xuetao, et al. GROWTH INHIBITION OF MELANOMA IN VIVO BY COMBINING ONCOSTATIN M GENE TRANSFECTION WITH LOCALIZED RADIATION: A GENE—RADIOTHERAPY STRATEGY FOR TUMOR. [J]. 辐射研究与辐射工艺学报 19(2):127-132(2001)
DOI：

Lü Xing, XING Ruiyun, PEI Xuetao, et al. GROWTH INHIBITION OF MELANOMA IN VIVO BY COMBINING ONCOSTATIN M GENE TRANSFECTION WITH LOCALIZED RADIATION: A GENE—RADIOTHERAPY STRATEGY FOR TUMOR. [J]. 辐射研究与辐射工艺学报 19(2):127-132(2001) DOI：

摘要

Abstract

探讨OSM对黑色素瘤体内生长的抑制作用及其在基因一放射治疗中的应用. 将人OSM cDNA插入pCI—neo构成OSM表达质粒 (pO) ; Egr—1基因调控序列 (Egr—1R) 连接于OSM cDNA上游构成辐射诱导性OSM表达质粒 (pEO) . pO和pEO转染小鼠B16黑色素瘤细胞, 筛选出OSM表达细胞 (pO—17和pEO—l) , 皮下接种C57小鼠, 观察和比较相同生长期内瘤体重量及给予,60,Co γ射线局部照射后肿瘤抑制率的变化. 结果表明; 在未照射实验中, pO—17和pEO—1细胞接种20d后的瘤体重量较对照组明显降低; 在照射实验中, pEO—1细胞照射后7d瘤体重量的下降最为显著, 肿瘤抑制率较未照射时提高42.3%. 说明转基困分泌的OSM可对瘤细胞的体内生长产生抑制; γ射线可通过Egr—1R增强OSM表达的途径, 加剧对肿瘤的抑制, 体现出基因-放射治疗的效果.

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MelanomaOncostatin MGene—radiotherapy

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GROWTH INHIBITION OF MELANOMA IN VIVO BY COMBINING ONCOSTATIN M GENE TRANSFECTION WITH LOCALIZED RADIATION: A GENE—RADIOTHERAPY STRATEGY FOR TUMOR

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