OXIDATION OF GUANINE AND GUANOSINE BY <inline-formula><alternatives><graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="media/1000-3436-19-02-012-I001.jpg" specific-use="print"/><graphic specific-use="big" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="alternativeImage/1000-3436-19-02-012-I001.jpg"/><graphic specific-use="small" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="alternativeImage/1000-3436-19-02-012-I001c.jpg"/></alternatives></inline-formula> RADICAL AT BASIC pH

ZHANG Zhouen; YAO Side; JIN Yizun; WANG Wenfen; LIN Weizhen; Qian Suping; Lin Nianyun

您当前的位置：

首页 >

文章列表页 >

OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH

研究简报 | 更新时间：2023-04-26

- OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH
- 辐射研究与辐射工艺学报 Vol. 19, Issue 2, Pages: 148-152(2001)
- 作者机构：
  
  1.复旦大学放射医学研究所上海 200032
  2.中国科学院上海原子核研究所辐射化学开放实验室上海 201800
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
ZHANG Zhouen, YAO Side, JIN Yizun, et al. OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH. [J]. 辐射研究与辐射工艺学报 19(2):148-152(2001)
DOI：

ZHANG Zhouen, YAO Side, JIN Yizun, et al. OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH. [J]. 辐射研究与辐射工艺学报 19(2):148-152(2001) DOI：

摘要

亚硝酸和,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767972&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767974&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767973&type=,自由基被证明为致DNA突变因子, 作为公认的氮原子中心的强氧化性亚硝基自由基,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767975&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767977&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767976&type=,对DNA的作用引起为数众多的科学家的关注, 但未观察到其直接作用的结果. 利用脉冲辐解技术在碱性条件下观察到,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767978&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767980&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767979&type=,直接氧化鸟嘌呤阴离子和鸟苷阴离子, 并测定pH12条件下,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767981&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767983&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767982&type=,氧化鸟嘌呤阴离子反应的速率常数k=1.3×10,8,dm,3,mol,-1,s,-1,. 但未观测到,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767984&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767952&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767985&type=,与脱氧鸟苷—5—磷酸及DNA的基他碱基的反应, 说明,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767986&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767988&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767987&type=,选择性氧化鸟嘌呤, 糖基和磷酸根及其组成的链具有保护DNA不被,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767989&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767991&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767990&type=,. 氧化的作用.

Abstract

Nitrogen doxide radical （,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767922&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767939&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767938&type=,） is known as a nitrogen centered free radical with powerful oxidizing properties. While ntric oxide and nitrous acid were prved to the able to cause mutation of DNA, the affect of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767940&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767956&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767955&type=, radical to DNA has being concerned by many scientists, but its direct result has not been observed. In this work, the reaction of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767957&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767960&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767959&type=, radical oxidizing guanine and guanosine in basic aqueous solution was observed directly by appoication of pulse radiolysis technique. Moreover,the rate constant of the reaction of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767961&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767965&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767963&type=, radical oxidizing guanine at pH 12, has been measured bo be ,k,=1.3×10,8,. But to reaction about ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767967&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767946&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767969&type=, radical with deoxyguanosine 5'—phosphate of other DNA bases was detected. It means that ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767970&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767950&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767948&type=, radical is a selective radical to oxidize guaine, and that the glucoside, phosphate and their link of DNA take the protective action against oxidation by nitrogen dioxide radical

关键词

亚硝基自由基鸟嘌呤鸟苷脉冲辐解

Keywords

Nitrogen dioxide radicalGuanineGuanosinePulse radiolysis

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

ONE-ELECTRON OXIDATION OF PHENANTHRENEQUINONE STUDIED BY PULSE RADIOLYSIS

ONE ELECTRON REDUCTION OF 9,10-PHENANTHRENE QUINONE STUDIED BY PULSE RADIOLYSIS

Related Author

No data

Related Institution

Beijing Normal University

North East Wales Institute, Mold Road

Department of Chemistry, Beijing Normal University

Faculty of Science and Technology, The North East Wales Institute

⁰

OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH

DOI：

摘要

Abstract

关键词

Keywords

references