SISTER CHROMATID EXCHANGE AND INHIBITION OF CELL PROLIFERATION RATIO INDEX BY IONIZING IRRADIATION AND ACTIVE OXYGEN SPECIES

Luo Liming; Zheng Rongliang; Lin Nianyun; Jin Yizun

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SISTER CHROMATID EXCHANGE AND INHIBITION OF CELL PROLIFERATION RATIO INDEX BY IONIZING IRRADIATION AND ACTIVE OXYGEN SPECIES

更新时间：2023-05-04

- SISTER CHROMATID EXCHANGE AND INHIBITION OF CELL PROLIFERATION RATIO INDEX BY IONIZING IRRADIATION AND ACTIVE OXYGEN SPECIES
- Journal of Radiation Research and Radiation Processing Vol. 13, Issue 2, Pages: 65-68(1995)
- 作者机构：
  
  1.兰州大学生物系，兰州　730000
  2.中国科学院辐射化学开放研究实验室，上海原子核所，上海　201800
  3.上海医科大学放射医学研究所，上海　200032
- 作者简介：
- 基金信息：
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Luo Liming, Zheng Rongliang, Lin Nianyun, et al. SISTER CHROMATID EXCHANGE AND INHIBITION OF CELL PROLIFERATION RATIO INDEX BY IONIZING IRRADIATION AND ACTIVE OXYGEN SPECIES. [J]. Journal of Radiation Research and Radiation Processing 13(2):65-68(1995)
DOI：

Luo Liming, Zheng Rongliang, Lin Nianyun, et al. SISTER CHROMATID EXCHANGE AND INHIBITION OF CELL PROLIFERATION RATIO INDEX BY IONIZING IRRADIATION AND ACTIVE OXYGEN SPECIES. [J]. Journal of Radiation Research and Radiation Processing 13(2):65-68(1995) DOI：

摘要

电离辐射、超氧阴离子自由基和羟自由基都能分别引起人淋巴细胞姊妹染色单体交换（SCE）频率增加和细胞增殖率指数降低。SCE与增殖率指数间密切负相关。推测电离辐射的上述生物学效应正是由辐照细胞生成的超氧阴离子和羟自由基引起的。

Abstract

Sister chromatid exchange (SCE) and inhibition of cell proliferation ratio index (PRI) in human lymphocytes were induced by ionizing irradiation, superoxide anions and hydroxyl radical. There was a negative relationship between SCE and PRI. It was suggested that those biological effects were caused by superoxide anions and hydroxyl radicals produced in irradiated cells.

关键词

电离辐射羟自由基超氧阴离子自由基姊妹染色单体交换细胞增殖率指数

Keywords

Ionizing irradiationHydroxyl radicalSuperoxide anionSister chromatid exchangeCell proliferation ratio index

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