ADAPTIVE RESPONSE OF HUMAN LYMPHOCYTES TO LOW DOSE RADIATION ON DNA SYNTHESIS

Du Zeji; Su Liaoyuan; Tian Hailin

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ADAPTIVE RESPONSE OF HUMAN LYMPHOCYTES TO LOW DOSE RADIATION ON DNA SYNTHESIS

更新时间：2023-05-04

- ADAPTIVE RESPONSE OF HUMAN LYMPHOCYTES TO LOW DOSE RADIATION ON DNA SYNTHESIS
- Journal of Radiation Research and Radiation Processing Vol. 13, Issue 2, Pages: 105-108(1995)
- 作者机构：
  
  1.苏州医学院放射医学系，苏州　215007
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Du Zeji, Su Liaoyuan, Tian Hailin. ADAPTIVE RESPONSE OF HUMAN LYMPHOCYTES TO LOW DOSE RADIATION ON DNA SYNTHESIS. [J]. Journal of Radiation Research and Radiation Processing 13(2):105-108(1995)
DOI：

Du Zeji, Su Liaoyuan, Tian Hailin. ADAPTIVE RESPONSE OF HUMAN LYMPHOCYTES TO LOW DOSE RADIATION ON DNA SYNTHESIS. [J]. Journal of Radiation Research and Radiation Processing 13(2):105-108(1995) DOI：

摘要

通过,3,H-TdR参入法研究了小剂量辐射诱导淋巴细胞DNA合成的适应性反应。结果表明，体外培养24 h的人外周血淋巴细胞经小剂量γ射线0.5—4.0 cGy照射后，均产生了适应性反应，诱导适应性反应的最适剂量为1.0 cGy。D,1,和D,2,照射间隔为24 h时，适应性反应最强，随时间间隔延长，适应性反应明显减弱。1 Gy～7 Gy的D,2,照射，均可显现适应性反应，3.0 Gy照射，反应表现最强，剂量过大，适应性反应不明显。

Abstract

Human peripheral blood lymphocytes PHA-stimulated in vitro for 24 h were exposed to low dose γ-ray irradiation (adaptive dose), they showed an adaptive response to the inhibition of DNA synthesis by subsequent higher acute doses of γ-ray (challenge dose). At the interval of 24h between adaptive dose and challenge dose, the most obvious adaptive response induced by low dose irradiation was found. It was also found that the response induced by 1.0 cGy of adaptive dose was more obvious than that by other doses. In the challenge doses range of 1.0~7.0 Gy, the adaptive response was observed and that 3.0 Gy was more obvious. The adaptive response disappeared with the challenge doses further increased.

关键词

小剂量辐射DNA合成适应性反应

Keywords

Low dose irradiationLymphocytesDNA synthesisAdaptive response

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