EFFECTS OF <sup>60</sup>Co γ RAYS ON THE CELL CYCLE PROGRESS OF MCF-7 CELLS

YANG Yepeng; CHEN Guanying; GUAN Zengwei; ZHOU Mei; SHEN Qinjian; SHEN Lei

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EFFECTS OF ⁶⁰Co γ RAYS ON THE CELL CYCLE PROGRESS OF MCF-7 CELLS

更新时间：2023-05-04

- EFFECTS OF ⁶⁰Co γ RAYS ON THE CELL CYCLE PROGRESS OF MCF-7 CELLS
- Journal of Radiation Research and Radiation Processing Vol. 20, Issue 4, Pages: 281-283(2002)
- 作者机构：
  
  1.北京大学医学部放射医学基础教研室　北京　100083
  2.北京大学医学部医药卫生分析中心　北京　100083
- 作者简介：
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YANG Yepeng, CHEN Guanying, GUAN Zengwei, et al. EFFECTS OF ⁶⁰Co γ RAYS ON THE CELL CYCLE PROGRESS OF MCF-7 CELLS. [J]. Journal of Radiation Research and Radiation Processing 20(4):281-283(2002)
DOI：

YANG Yepeng, CHEN Guanying, GUAN Zengwei, et al. EFFECTS OF ⁶⁰Co γ RAYS ON THE CELL CYCLE PROGRESS OF MCF-7 CELLS. [J]. Journal of Radiation Research and Radiation Processing 20(4):281-283(2002) DOI：

摘要

以,60,Co γ射线照射体外培养的人乳腺癌MCF-7细胞 ,运用流式细胞术探讨了受照射后细胞周期进程的变化规律。结果表明 ,MCF-7细胞受5.0Gy γ照射后呈现短暂的,S,期阻滞(持续约6h) ,主要为,G,2,期阻滞 (持续约63h)。,S,期和,G,2,期阻滞高峰分别出现在照射后9h和18h ,阻滞峰值分别达正常值的1.6倍和6.2倍。照射后9h和照射后18h的剂量—效应曲线截然不同。照射后9h ,S,期阻滞和照射后18h ,G,2,期阻滞均与照射剂量呈现明显剂量—效应关系。

Abstract

To investigate the effects of ionizing radiation on cell cycle progress of tumor cell lines, the human breast cancer MCF-7 cell line cultured in vitro was exposed to ,60,Co γ rays and the alterations in cell cycle progress after irradiation were measured by flow cytometry.The results indicated that the MCF-7 cells showed a transient ,S, arrest continuing for about 6h and an obvious ,G,2, arrest continuing for about 63h after irradiation with 5.0Gy γ rays. ,S, and ,G,2, arrest culminated at 9h and 18h respectively after irradiation and the peak values of ,S, and ,G,2, arrest reached respectively 1.6 times and 6.2 times as many as normal value. The dose-effect curve examined 9h after irradiation was quite different from that examined 18h after irradiation. Both of the ,S, arrest at 9h after irradiation and the ,G,2, arrest at 18h after irradiation presented significant relationship with irradiation dose.

关键词

电离辐射MCF-7细胞细胞周期

Keywords

Ionizing radiationMCF-7 cell lineCell cycle

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EFFECTS OF 60Co γ RAYS ON THE CELL CYCLE PROGRESS OF MCF-7 CELLS

DOI：

摘要

Abstract

关键词

Keywords

references

EFFECTS OF ⁶⁰Co γ RAYS ON THE CELL CYCLE PROGRESS OF MCF-7 CELLS