γ-IRRADIATED CROSSLINKING OF THYMINE IN N<sub>2</sub>O SATURATED AQUEOUS SOLUTION

Zhao Rong; Lin Nianyun; Zhang Jiashan

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γ-IRRADIATED CROSSLINKING OF THYMINE IN N₂O SATURATED AQUEOUS SOLUTION

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- γ-IRRADIATED CROSSLINKING OF THYMINE IN N₂O SATURATED AQUEOUS SOLUTION
- Journal of Radiation Research and Radiation Processing Vol. 8, Issue 1, Pages: 48-53(1990)
- 作者机构：
  
  中国科学院上海原子核研究所，上海
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1990-02，
  
  Received：06 March 1989，
- 稿件说明：
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Zhao Rong, Lin Nianyun, Zhang Jiashan. γ-IRRADIATED CROSSLINKING OF THYMINE IN N₂O SATURATED AQUEOUS SOLUTION. [J]. Journal of Radiation Research and Radiation Processing, 1990,8(1):48-53.
DOI：

Zhao Rong, Lin Nianyun, Zhang Jiashan. γ-IRRADIATED CROSSLINKING OF THYMINE IN N₂O SATURATED AQUEOUS SOLUTION. [J]. Journal of Radiation Research and Radiation Processing, 1990,8(1):48-53. DOI：

摘要

本文研究了在N

O饱和水溶液体系中，胸腺嘧啶的γ-辐解产物。用纸层析放射性分析法，测得胸腺嘧啶交联二聚体的产额G=2.6。用高效液相色谱放射性检测法和色谱质谱联用法，检测和鉴定胸腺嘧啶交联二聚体的结构，确定胸腺嘧啶交联二聚体是以嘧啶环上C（5）-C（5）单键连接的化合物，它们的进一步反应，形成各种不同结构的交联产物。

Abstract

In this work radioactive paper chromatograph was used to separate γ-irradiated products of 2-

C labelled thymine in N

O saturated solution and the G value of thymine dimers was determined to be 2.6. The preparative paper chromatography was adoped to isolate the dimers preliminary and then a high performance liquid chromatography equiped with a radiocativity detector was applied to separate both the preliminary isolated dimers and untreated sample. For further structure characterization of dimers a capillary gas chromatography-mass spectrometry (GC-MS)was used and the mass spectra were taken from each GC separated product peak of

-irradiated thymine in N

O saturated solution after trimethylsilylation by BSTFA. TMS derivatives of radiation induced dimers of thymine showed the molecular ion(M

) and a characteristic ion (M- CH

)

at 718

703; 628

613; 538

523; 540

525; These peaks were assigned to the following structures from several kinds of radical combination

such as

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The dehydration of this dimer derives a variety of crosslinked products:

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TMS derivatives

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Another kind of crosslinking is

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关键词

胸腺嘧啶辐射交联GC-MSHPLC

Keywords

ThymineRadiation CrosslinkingGC-MSHPLC

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γ-IRRADIATED CROSSLINKING OF THYMINE IN N2O SATURATED AQUEOUS SOLUTION

DOI：

摘要

Abstract

关键词

Keywords

references

γ-IRRADIATED CROSSLINKING OF THYMINE IN N₂O SATURATED AQUEOUS SOLUTION