STUDIES OF SCAVENGING EFFECTS ON ACTIVE OXYGENS OF CHINONIN

Zhang Hongyu; Wang Fuyuan; Li Ming; Zhang Zhiyi; Li Meifen

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STUDIES OF SCAVENGING EFFECTS ON ACTIVE OXYGENS OF CHINONIN

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- STUDIES OF SCAVENGING EFFECTS ON ACTIVE OXYGENS OF CHINONIN
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 4, Pages: 224-228(1997)
- 作者机构：
  
  中国科学院生物物理所　北京　100101
  1.深圳银湖南方制药厂三九药业医药研究院生化室　深圳　518029
- 作者简介：
  
  2To whom correspondence should be addressed
- 基金信息：
- DOI：
  CLC：
- Published：1997-11，
  
  Received：20 May 1996，
  
  Revised：01 August 1996，
- 稿件说明：
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Zhang Hongyu, Wang Fuyuan, Li Ming, et al. STUDIES OF SCAVENGING EFFECTS ON ACTIVE OXYGENS OF CHINONIN. [J]. Journal of Radiation Research and Radiation Processing, 1997,15(4):224-228.
DOI：

Zhang Hongyu, Wang Fuyuan, Li Ming, et al. STUDIES OF SCAVENGING EFFECTS ON ACTIVE OXYGENS OF CHINONIN. [J]. Journal of Radiation Research and Radiation Processing, 1997,15(4):224-228. DOI：

摘要

用ESR及自旋捕捉技术研究了知母宁（从中药知母中提取的有四个酚羟基的

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酮化合物）在均相和非均相体系中对•OH、

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和

等几种活性氧的清除、猝灭效果。发现知母宁对•OH、

均有较强的清除和猝灭作用，效果好于维生素E，并通过动力学方法求得其在均相体系中对

的猝灭速率常数为7.2×10

mol

-1

L S

-1

。

Abstract

Chinonin

a kind of xanthonoid compound with four phenolic hydroxyls

is extracted from Anemarrhena asphodeloides Bunge

a sort of traditional Chinese medicine. In this paper

ESR and spin trapping techniques are used to study its scavenging effects on •OH

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and

in homogeneous and heterogeneous system. It is found that chinonin possesses fairly strong scavenging activity on •OH and

which is better than that of V

. Through kinetic method

quenching rate constant of chinonin on

is determined as 7.2×10

mol

-1

L s

-1

关键词

知母宁活性氧ESR自旋捕捉

Keywords

ChinoninActive oxygenESRSpin trapping

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