COMPARISON OF RADIATION EFFECTS IN HUMAN HEPATOMA CELL LINE SMMC-7721 IRRADIATED BY 30MeV/u 40 Ar15+ AND 60Co γ-RAY

Wang Jufang; Zhou Guangming; Li Wenjian; Chen Weiqiang; Wei Zengquan; Gao Qingxiang; Yang Hanmin

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COMPARISON OF RADIATION EFFECTS IN HUMAN HEPATOMA CELL LINE SMMC-7721 IRRADIATED BY 30MeV/u ⁴⁰ Ar¹⁵⁺ AND ⁶⁰Co γ-RAY

更新时间：2024-11-05

- COMPARISON OF RADIATION EFFECTS IN HUMAN HEPATOMA CELL LINE SMMC-7721 IRRADIATED BY 30MeV/u ⁴⁰ Ar¹⁵⁺ AND ⁶⁰Co γ-RAY
- Journal of Radiation Research and Radiation Processing Vol. 15, Issue 4, Pages: 249-252(1997)
- 作者机构：
  
  1.中国科学院近代物理研究所　兰州　730000
  2.兰州大学生物系　兰州　730000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：1997-11，
  
  Received：13 August 1996，
  
  Revised：14 October 1996，
- 稿件说明：
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Wang Jufang, Zhou Guangming, Li Wenjian, et al. COMPARISON OF RADIATION EFFECTS IN HUMAN HEPATOMA CELL LINE SMMC-7721 IRRADIATED BY 30MeV/u ⁴⁰ Ar¹⁵⁺ AND ⁶⁰Co γ-RAY. [J]. Journal of Radiation Research and Radiation Processing, 1997,15(4):249-252.
DOI：

Wang Jufang, Zhou Guangming, Li Wenjian, et al. COMPARISON OF RADIATION EFFECTS IN HUMAN HEPATOMA CELL LINE SMMC-7721 IRRADIATED BY 30MeV/u ⁴⁰ Ar¹⁵⁺ AND ⁶⁰Co γ-RAY. [J]. Journal of Radiation Research and Radiation Processing, 1997,15(4):249-252. DOI：

摘要

比较了重离子30MeV/u

15+

和

Co γ射线对体外培养的人肝癌细胞株SMMC-7721的辐射效应，用活体和固定的方法观察了辐射处理后细胞死亡的过程。结果表明：无论是重离子还是γ射线，都能对细胞造成严重损伤，影响细胞存活百分数；同时，重离子比γ射线对细胞有更显著的杀伤效果，在处理后第48h，细胞存活率为50%时，重离子的RBE约为1.5。

Abstract

Radiation effects of cultured human hepatoma cell line SMMC-7721 irradiated by heavy ion 30MeV/u

15+

and

Co γ-ray are compared in this study. Process of the cell death after irradiation is studied by observing the alive cells and the fixed cells. The results show that both heavy ion and γ-ray can cause serious damage to the cells

and affect the cell survival fraction. Meanwhile

the killing effect on cells by heavy ion is stronger than that by γ-ray. At the 48th hour after treatment

the relative biological effectiveness of heavy ion is 1.5 based on cell survival of 50%.

关键词

重离子γ射线人肝癌细胞存活百分数相对生物学效应（RBE）

Keywords

Heavy ionγ-rayHuman hepatoma cell lineSurvival fractionRelative biological effectiveness

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