The effects of radiation degradation on the properties and structure of various polysulfone under various irradiations, such as electronic beam irradiation, γ-irradiation and heavy ion irradiation have been reviewed and discussed in this paper. It has been shown that the previous studies are mainly concerned with degradation mechanism, the kinds of gas products, radiation chemical yields of degraded polysulfone and the relationship between properties and constructure of irradiated polysulfone. However the basic studies were insufficient to estimate the applied lifetime of polysulfones under irradiation situation. And the achievements are helpful for understanding the degradation behavior of various polysulfones under irradiation.