低剂量<sup>60</sup>Co γ线诱发人血淋巴细胞早熟凝聚染色体畸变的剂量效应曲线研究

冯嘉林; 邵松生; 林雅萍; 刘红珍; 邹美君

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低剂量⁶⁰Co γ线诱发人血淋巴细胞早熟凝聚染色体畸变的剂量效应曲线研究

更新时间：2023-04-23

- 低剂量⁶⁰Co γ线诱发人血淋巴细胞早熟凝聚染色体畸变的剂量效应曲线研究
- DOSE RESPONSE CURVE FOR HUMAN BLOOD LYMPHOCYTE CHROMOSOME ABERRATIONS INDUCED BY ⁶⁰CO γ RADIATION OF LOW DOSES USING PREMATURE CONDENSED CHROMOSOME (PCC)
- 辐射研究与辐射工艺学报 1990年8卷第2期页码：107-110
- 作者机构：
  
  1.上海医科大学放射医学研究所，上海
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冯嘉林, 邵松生, 林雅萍, 等. 低剂量⁶⁰Co γ线诱发人血淋巴细胞早熟凝聚染色体畸变的剂量效应曲线研究[J]. 辐射研究与辐射工艺学报, 1990,8(2):107-110.

Feng Jialin, Shao Songsheng, Lin Yaping, et al. DOSE RESPONSE CURVE FOR HUMAN BLOOD LYMPHOCYTE CHROMOSOME ABERRATIONS INDUCED BY ⁶⁰CO γ RADIATION OF LOW DOSES USING PREMATURE CONDENSED CHROMOSOME (PCC)[J]. Journal of Radiation Research and Radiation Processing, 1990,8(2):107-110.
冯嘉林, 邵松生, 林雅萍, 等. 低剂量⁶⁰Co γ线诱发人血淋巴细胞早熟凝聚染色体畸变的剂量效应曲线研究[J]. 辐射研究与辐射工艺学报, 1990,8(2):107-110. DOI：

Feng Jialin, Shao Songsheng, Lin Yaping, et al. DOSE RESPONSE CURVE FOR HUMAN BLOOD LYMPHOCYTE CHROMOSOME ABERRATIONS INDUCED BY ⁶⁰CO γ RADIATION OF LOW DOSES USING PREMATURE CONDENSED CHROMOSOME (PCC)[J]. Journal of Radiation Research and Radiation Processing, 1990,8(2):107-110. DOI：

摘要

本文报道应用人外周血淋巴细胞在离体条件下，用低剂量,60,Co γ线照射后与M期CHO细胞融合产生G,1,-PCC，计数其畸变产额，得到线性剂量效应刻度曲线，,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649522&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649544&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649543&type=,r,=0.99，并与常规细胞遗传学方法作了比较，结果表明G,1,-PCC方法比常规遗传学方法快速、灵敏。对其作为生物剂量计尚存在的问题也进行了讨论。

Abstract

The human blood was irradiated in vitro by 0-100 10,-2,Gy. Then the lymphocytes were separated from the whole blood. The mitotic CHO cells fused with lymphocytes. This technique can be used to visualize damage to interphase chromosome aberrations after irradiation. The frequency of breaks produced in G,1, phase of the lymphocytes is scord. The dose-response curve for chromosome fragments was found to be linear ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649545&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649527&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649526&type=, r=0.99. The method was compared with conventional cytogenetic. The results presented that the G,1,-PCC technique is more rapidly and sensitively. But the G,1 ,-PCC used technique of biological dosimetry has some questions which is discussed.

关键词

早熟凝聚染色体染色体畸变断裂

Keywords

Premature condensation chromosomeAberrationBreakguestions

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低剂量60Co γ线诱发人血淋巴细胞早熟凝聚染色体畸变的剂量效应曲线研究

DOSE RESPONSE CURVE FOR HUMAN BLOOD LYMPHOCYTE CHROMOSOME ABERRATIONS INDUCED BY 60CO γ RADIATION OF LOW DOSES USING PREMATURE CONDENSED CHROMOSOME (PCC)

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Abstract

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references

低剂量⁶⁰Co γ线诱发人血淋巴细胞早熟凝聚染色体畸变的剂量效应曲线研究

DOSE RESPONSE CURVE FOR HUMAN BLOOD LYMPHOCYTE CHROMOSOME ABERRATIONS INDUCED BY ⁶⁰CO γ RADIATION OF LOW DOSES USING PREMATURE CONDENSED CHROMOSOME (PCC)