小剂量辐照小鼠胸腺细胞膜流动性的变化

谢国梁; 么燕玉; 郝春风; 孙福聚; 王莉虹

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小剂量辐照小鼠胸腺细胞膜流动性的变化

更新时间：2023-04-23

- 小剂量辐照小鼠胸腺细胞膜流动性的变化
- CHANGES OF THYMOCYTE MEMBRANE FLUIDITY IN MICE INDUCED BY LOW DOSE ⁶⁰Co γ IRRADIATION
- 辐射研究与辐射工艺学报 1992年10卷第3期页码：179-181
- 作者机构：
  
  1.河北省放射卫生研究所，石家庄
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谢国梁, 么燕玉, 郝春风, 等. 小剂量辐照小鼠胸腺细胞膜流动性的变化[J]. 辐射研究与辐射工艺学报, 1992,10(3):179-181.

Xie Guoliang, Yao Yanyu, Hao Chunfong, et al. CHANGES OF THYMOCYTE MEMBRANE FLUIDITY IN MICE INDUCED BY LOW DOSE ⁶⁰Co γ IRRADIATION[J]. Journal of Radiation Research and Radiation Processing, 1992,10(3):179-181.
谢国梁, 么燕玉, 郝春风, 等. 小剂量辐照小鼠胸腺细胞膜流动性的变化[J]. 辐射研究与辐射工艺学报, 1992,10(3):179-181. DOI：

Xie Guoliang, Yao Yanyu, Hao Chunfong, et al. CHANGES OF THYMOCYTE MEMBRANE FLUIDITY IN MICE INDUCED BY LOW DOSE ⁶⁰Co γ IRRADIATION[J]. Journal of Radiation Research and Radiation Processing, 1992,10(3):179-181. DOI：

摘要

报道了以茈为荧光探针，探讨小剂量,60,Co γ射线照射后小鼠胸腺细胞膜流动性的变化。结果表明，剂量在0.25—1.00 Gy范围，胸腺细胞膜流动性降低与剂量之间呈明显线性关系。从0.50 Gy起，辐照组荧光强度比值I,1,/I,2,与I,3,/I,2,与对照组的比较存有显著差异(P,<,0.05）。提示淋巴细胞膜流动性的变化可作为小剂量辐照早期效应的敏感指标。

Abstract

The changes of thymocyte membrane fluidity in mice induced by low-dose ,60,Co ,γ, irradiation from pyrene fluorescent probe were reported. The results showed that the fluidity was decreased with increase of irradiation dose (0.25—1.00 Gy). The relationship between the ratio of I,1,/I,2, or I,3,/L,2, and irradiation dose were significantlycorrelative. From 0.50 to 1.00 Gy both ratios were significantly different as compared with contorl. The results can be used as sensitive indexes for early radiation effects.

关键词

小剂量电离辐射胸腺细胞细胞膜流动性荧光探针

Keywords

Low-dose ionizing radiationThymocyteFluidity of cell membraneFluorescent probe

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