<sup>238</sup>Pu α粒子照射对类巨噬细胞（P388D<sub>1</sub>）免疫功能的影响

樊飞跃; 龚诒芬; 吴德昌; 刘国廉

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²³⁸Pu α粒子照射对类巨噬细胞（P388D₁）免疫功能的影响

研究论文 | 更新时间：2023-05-04

- ²³⁸Pu α粒子照射对类巨噬细胞（P388D₁）免疫功能的影响
- RADIATION EFFECT OF α-PARTICLES ON IMMUNOLOGICAL FUNCTION OF MACROPHAGE CELL LINE (P 388D₁)
- 辐射研究与辐射工艺学报 1995年13卷第2期页码：74-78
- 作者机构：
  
  1.放射医学研究所，北京　100850
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樊飞跃, 龚诒芬, 吴德昌, 等. ²³⁸Pu α粒子照射对类巨噬细胞（P388D₁）免疫功能的影响[J]. 辐射研究与辐射工艺学报, 1995,13(2):74-78.

Fan Feiyue, Gong Yifen, Wu Dechang, et al. RADIATION EFFECT OF α-PARTICLES ON IMMUNOLOGICAL FUNCTION OF MACROPHAGE CELL LINE (P 388D₁)[J]. Journal of Radiation Research and Radiation Processing, 1995,13(2):74-78.
樊飞跃, 龚诒芬, 吴德昌, 等. ²³⁸Pu α粒子照射对类巨噬细胞（P388D₁）免疫功能的影响[J]. 辐射研究与辐射工艺学报, 1995,13(2):74-78. DOI：

Fan Feiyue, Gong Yifen, Wu Dechang, et al. RADIATION EFFECT OF α-PARTICLES ON IMMUNOLOGICAL FUNCTION OF MACROPHAGE CELL LINE (P 388D₁)[J]. Journal of Radiation Research and Radiation Processing, 1995,13(2):74-78. DOI：

摘要

吸入有害因子，特别是难溶性粒子后，肺巨噬细胞是最先受到损害的一类免疫活性细胞。研究α粒子对巨噬细胞免疫功能的效应，在阐明吸入难溶性α粒子对机体免疫功能损伤中具有重要的意义。本文以类巨噬细胞（P 388 D,1,）作为巨噬细胞的模拟细胞，用,238,Pu电镀源作为α辐射源，观察了α辐射对巨噬细胞免疫吞噬功能和Fc受体表达功能的影响，及这两项免疫指标对,α,辐射敏感性的差异。接受较大剂量或照射后较长时间，细胞吞噬功能明显下降。随着剂量增加，细胞吞噬功能下降的速率较之Fc受体功能下降速率更快。提示细胞吞噬功能对,α,辐射的敏感性比Fc受体更高。照射后早期接受较小剂量照射，细胞吞噬功能呈增强性改变。

Abstract

The α-particles effects on the functions of phagocytosis and receptor Fc of macrophage were studied, in which α-irradiation was emitted from ,238,Pu source and macrophage like cell line P 388 D,1, were tested. Difference of sensitivities between phagocytosis and receptor Fc to α-irradiation was analysed. The changes differed with different durations of post-irradiation and doses of α-irradiation. Phagocytic function was enhanced during early period of post-radiation by low dose irradiation. Phagocytic function decreased certainly under large doses and/or long duration of post-irradiation. Relationship between doses and effects on suppression of phagocytosis was definite, which was a model of single decrease and suited to formula of minus exponent. Trend of suppressive changes both phagocytosis and receptor Fc was compared. The result indicated that the decrease of phagocytosis with increase of doses was faster than that of receptor Fc. It was suggested that phagocytosis was more sensitive to α-irradiation than function of receptor Fc.

关键词

α粒子类巨噬细胞免疫功能

Keywords

α-irradiationPhagocyteImmunology

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238Pu α粒子照射对类巨噬细胞（P388D1）免疫功能的影响

RADIATION EFFECT OF α-PARTICLES ON IMMUNOLOGICAL FUNCTION OF MACROPHAGE CELL LINE (P 388D1)

DOI：

摘要

Abstract

关键词

Keywords

references

²³⁸Pu α粒子照射对类巨噬细胞（P388D₁）免疫功能的影响

RADIATION EFFECT OF α-PARTICLES ON IMMUNOLOGICAL FUNCTION OF MACROPHAGE CELL LINE (P 388D₁)