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GUAN Haiyan HU Daqiang OU Shunlong LU Laichun

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- Journal of Radiation Research and Radiation Processing Vol. 31, Issue 1, Pages: 9-010303(2013)
- 作者机构：
  
  1. （第三军医大学大坪医院野战外科研究所药剂科）,重庆,400042
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GUAN Haiyan HU Daqiang OU Shunlong LU Laichun. [J]. Journal of Radiation Research and Radiation Processing 31(1):9-010303(2013)
DOI：

GUAN Haiyan HU Daqiang OU Shunlong LU Laichun. [J]. Journal of Radiation Research and Radiation Processing 31(1):9-010303(2013) DOI：

摘要

以不同剂量γ射线模拟辐照环境，考察氢化可的松注射液的稳定性。将同一批号的氢化可的松注射液经60Co γ射线辐照，吸收剂量设定为2、4、8、16、26和34 kGy。观察注射液颜色和澄明度的变化，并采用高效液相色谱（HPLC）法测定氢化可的松注射液含量变化。结果表明：氢化可的松注射液含量随吸收剂量显著下降（p＜0.01），当吸收剂量为2 kGy以上时含量下降超出质量合格范围；氢化可的松经辐照后变浑浊，颜色也经历先变黄后又无色，提示氢化可的松溶液中生成了溶解度较小的物质，在辐照环境中极不稳定。

Abstract

The same batches of hydrocortisone injection were irradiated by 60Co γ-rays with different absorbed doses of 2, 4, 8, 16, 26, and 34 kGy, respectively. The color and clarity of hydrocortisone injection were inspected and the content of hydrocortisone was analyzed by HPLC. The results show that the injection content decreases with the increment of absorbed doses (p<0.01), and it is out of the control quality when the absorbed dose more than 2 kGy. Moreover the color becomes yellow and then is transferred transparent. The hydrocortisone injection is unstable to radiation as it will generate some colored and less soluble substances under radiation environment.Cited

关键词

氢化可的松辐照稳定性高效液相色谱

Keywords

HydrocortisoneIrradiationStabilityHPLC

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