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WANG Lu PENG Mingli GUO Lili TIAN Yunling HUA Kai CHENG Wu CHEN Chao CUI Yali

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- Journal of Radiation Research and Radiation Processing Vol. 31, Issue 3, Pages: 6-030205(2013)
- 作者机构：
  
  1. 1（国家微检测系统工程技术研究中心西安 710069） 2（合成与天然功能分子化学教育部重点实验室西北大学化学与材料科学学院 ),西安,710069
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WANG Lu PENG Mingli GUO Lili TIAN Yunling HUA Kai CHENG Wu CHEN Chao CUI Yali. [J]. Journal of Radiation Research and Radiation Processing 31(3):6-030205(2013)
DOI：

WANG Lu PENG Mingli GUO Lili TIAN Yunling HUA Kai CHENG Wu CHEN Chao CUI Yali. [J]. Journal of Radiation Research and Radiation Processing 31(3):6-030205(2013) DOI：

摘要

为满足葡聚糖磁性复合微粒临床无菌应用要求，采用60Co γ射线对该微粒进行辐照灭菌处理，考察吸收剂量为9 kGy、15 kGy和25 kGy时对其物理化学性质的影响，并对灭菌微粒进行无菌检查及方法验证。结果表明：该磁性复合微粒在3种吸收剂量下均表现出良好的稳定性，其物理化学性质均未出现明显变化；经辐照灭菌的微粒达到10-1的无菌保证水平，已建立的无菌检查方法可靠。

Abstract

Dextran composite magnetic nanoparticles (DCMn) were expected to be a magnetically-targeted carrier for clinical anticancer drug delivery. The feasibility of sterilization of the DCMn using 60Co γ-rays irradiation was investigated with different absorbed doses of 9 kGy, 15 kGy, and 25 kGy. A sterility test for the particles and the validation of test was performed. The DCMn showed excellent stability with the investigated irradiation dosage range. The test results showed that irradiation did not influence the physicochemical properties of DCMn, and the radiated DCMn reached the 10-1 sterilization level and the sterility test was stable and reliable.Cited

关键词

葡聚糖磁性复合微粒辐照灭菌剂量

Keywords

Dextran composite magnetic nanoparticles(DCMn)SterilizationDose

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Department of Radiation Medicine and Protection, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Faculty of Preventive Medicine, Air Force Medical University

School of Public Health, Shaanxi University of Chinese Medicine

Department of Radiation Biology, Faculty of Preventive Medicine, Air Force Medical University

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