INJURY MECHANISM OF OXIDATIVE FREE RADICALS INDUSED BY CARBON DISULFIDE ON TARGET OF BIO-MOLECULES

JIAN Le; QIAN Suping; YAO Side; JIANG Huai

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INJURY MECHANISM OF OXIDATIVE FREE RADICALS INDUSED BY CARBON DISULFIDE ON TARGET OF BIO-MOLECULES

更新时间：2023-03-30

- INJURY MECHANISM OF OXIDATIVE FREE RADICALS INDUSED BY CARBON DISULFIDE ON TARGET OF BIO-MOLECULES
- Journal of Radiation Research and Radiation Processing Vol. 21, Issue 1, Pages: 45-48(2003)
- 作者机构：
  
  1.浙江大学医学院劳动卫生与环境卫生研究所　杭州　310006
  2.中国科学院上海原子核研究所辐射化学开放实验室　上海　201800
- 作者简介：
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JIAN Le, QIAN Suping, YAO Side, et al. INJURY MECHANISM OF OXIDATIVE FREE RADICALS INDUSED BY CARBON DISULFIDE ON TARGET OF BIO-MOLECULES. [J]. Journal of Radiation Research and Radiation Processing 21(1):45-48(2003)
DOI：

JIAN Le, QIAN Suping, YAO Side, et al. INJURY MECHANISM OF OXIDATIVE FREE RADICALS INDUSED BY CARBON DISULFIDE ON TARGET OF BIO-MOLECULES. [J]. Journal of Radiation Research and Radiation Processing 21(1):45-48(2003) DOI：

摘要

利用脉冲辐解技术研究了二硫化碳（CS,2,）被氧化生成的阳离子自由基，以时间分辨瞬态吸收光谱方法获取CS,2,阳离子自由基的特征吸收谱。同时，研究了CS,2,阳离子自由基损伤生物靶分子的机理，测定了相关的反应动力学常数。结果发现, CS,2,阳离子自由基能与DNA、dGMP、酪氨酸和色氨酸反应产生新的产物，在CS,2,对生物靶分子的氧化损伤中可能起着重要的作用。

Abstract

Pulse radiolysis technique was used to probe the generation of radical cations from carbon disulfide, and characteristic absorbance spectra of the radical cations were obtained by time-resolved transient absorbance spectrum method. The injury mechanism of the bio-molecular targets by the free radicals and relative constants of reaction kinetics were studied. Results showed that the radical cations could react with DNA, dGMP, tyrosine and tryptophan and form new products, which may play an important role in oxidative injury on bio-molecules by carbon disulfide.

关键词

二硫化碳阳离子自由基脱氧鸟苷酸脱氧核糖核酸酪氨酸色氨酸

Keywords

Carbon disulfideRadical cationsdGMPDNATyrosineTryptophan

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