HORMESIS OF LOW DOSE RADIATION ON THE EXPRESSION OF CYTOKINES IN UMBILICAL CORD BLOOD

CAI Weibo; ZOU Zhenghui; Qiu Jianmin; Yang Shuxian; Xu Meijuan; ZHANG Yuying; Su Liaoyuan

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HORMESIS OF LOW DOSE RADIATION ON THE EXPRESSION OF CYTOKINES IN UMBILICAL CORD BLOOD

更新时间：2023-03-30

- HORMESIS OF LOW DOSE RADIATION ON THE EXPRESSION OF CYTOKINES IN UMBILICAL CORD BLOOD
- Journal of Radiation Research and Radiation Processing Vol. 21, Issue 2, Pages: 154-156(2003)
- 作者机构：
  
  1.苏州市第二人民医院血液科　苏州　215002
  1a.苏州市第二人民医院妇产科　苏州　215002
  2.苏州大学第二附属医院血液科　苏州　215003
  3.苏州大学核医学院放射生物室　苏州　215006　
  4.苏州市第四人民医院核医学科　苏州　215007
- 作者简介：
- 基金信息：
- DOI：
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CAI Weibo, ZOU Zhenghui, Qiu Jianmin, et al. HORMESIS OF LOW DOSE RADIATION ON THE EXPRESSION OF CYTOKINES IN UMBILICAL CORD BLOOD. [J]. Journal of Radiation Research and Radiation Processing 21(2):154-156(2003)
DOI：

CAI Weibo, ZOU Zhenghui, Qiu Jianmin, et al. HORMESIS OF LOW DOSE RADIATION ON THE EXPRESSION OF CYTOKINES IN UMBILICAL CORD BLOOD. [J]. Journal of Radiation Research and Radiation Processing 21(2):154-156(2003) DOI：

摘要

探讨低剂量辐射(LDR)对脐血细胞因子表达的刺激效应。以,226,Ra γ射线作为辐射源, 以5cGy作为刺激量, 用放射免疫方法（RIA）检测脐血血浆中白介素2（IL-2）、白介素8（IL-8）、红细胞生长素（EPO）及超氧化物岐化酶-1（SOD-1）的活性水平。经过5cGy刺激1h后，脐血血浆中IL-2、IL-8、EPO及SOD-1活性水平均上调，与0cGy比较均有显著性差别(,p,<,0.05)。其中, EPO具有非常显著差别(,p,<,0.01)。 5cGy LDR对脐血IL-2、IL-8、EPO及SOD-1活性具有刺激效应。

Abstract

The paper studies hormesis of low dose radiation (LDR)in the expression of cytokines in umbilical cord blood (UCB). 1h after irradiation of UCB with 5cGy of ,226,Ra γ-rays, the levels of IL-2, IL-8 EPO and SOD-1 were determined by radioimmunoassay (RIA). Compared with the control (0Gy), the levels of all the assayed cytokines in the irradiated samples were up-regulated, with significant differences for IL-2, IL-8 and SOD-1 (,p,<,0.05) and very significant difference for EPO (,p,<,0.01). LDR with ,226,Ra γ-rays could induce hormesis as to the expression of IL-2, IL-8, EPO and SOD-1 in UCB.

关键词

低剂量辐射刺激效应脐血细胞因子

Keywords

Low dose radiationHormesisUmbilical cord bloodCytokines

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