A Research on the correspondence between GSH content and cancer radiosensitivity

KONG Zhaolu; JIN Yizun; SHEN Zhifen; TONG Sungao

您当前的位置：

首页 >

文章列表页 >

A Research on the correspondence between GSH content and cancer radiosensitivity

更新时间：2023-03-30

- A Research on the correspondence between GSH content and cancer radiosensitivity
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 3, Pages: 161-164(2004)
- 作者机构：
  
  1.复旦大学放射医学研究所　上海　200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
KONG Zhaolu, JIN Yizun, SHEN Zhifen, et al. A Research on the correspondence between GSH content and cancer radiosensitivity. [J]. Journal of Radiation Research and Radiation Processing 22(3):161-164(2004)
DOI：

KONG Zhaolu, JIN Yizun, SHEN Zhifen, et al. A Research on the correspondence between GSH content and cancer radiosensitivity. [J]. Journal of Radiation Research and Radiation Processing 22(3):161-164(2004) DOI：

摘要

实验从细胞和动物水平研究射线对肿瘤细胞中谷胱苷肽（GSH）合成的影响，分析GSH含量同肿瘤辐射敏感性的相关性；评价GSH合成抑制剂-丁胱亚磺酰亚胺（BSO）的辐射增敏效果，探讨以外周血单核细胞中GSH含量监测肿瘤患者对射线敏感性的可行性。实验结果表明，射线可以引起肿瘤细胞中GSH含量的升高，抑制肿瘤组织中GSH的合成，可以显著增强肿瘤细胞对射线的敏感性，外周血单核细胞和肿瘤中GSH含量变化一致且与肿瘤细胞对射线的敏感性相关。

Abstract

The present study aims to analyze the correspondence between intracellular gluthathione (GSH) content and tumour cells sensitivity to γ-rays, to investigate the influence of irradiation on GSH synthesis and to evaluate the feasibility of monitoring patients radiosensitivity by determining GSH in peripheral monocyto. In this experiments, buthionine sulfoximine (BSO), a GSH synthase inhibitor used to adjust intracellular GSH content, was observed its radiosensitization effect in vivo and in vitro. The results indicated that irradiation increased GSH synthese, BSO enhanced cells sensitivity to γ-ray by exhausting intracellulsr GSH, GSH in PMN could be an useful biochemical parameter to monitor patients sensitivity to irradiation.

关键词

谷胱甘肽谷胱甘肽过氧化物酶γ射线丁胱亚磺酰亚胺辐射敏感性

Keywords

glutathioneglutathione peroxidaseγ-raysbuthionine sulfoximineradiosensitization

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

THE PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN GLUTATHIONE CONTENT IN HUMAN SGC7901 CELL LINE PRETREATED WITH RADIOSENSITIZER AND ITS SUFFERED RADIATION DOSE

Radiolysis of aqueous solution containing copper ions

Effects of gamma-ray irradiation on cognitive function and neuronal death in mice

Optically stimulated luminescence performance of AlON:C transparent ceramics

Development of a new biodosimetry of serum iron

Related Author

No data

Related Institution

Shanghai Institute of Radiation Medicine, Fudan University

National Synchrotron Radiation Laboratory, University of Science and Technology of China

School of Nuclear Science and Technology, University of Science and Technology of China

Department of Radiation Medicine, School of Public Health, University of South China

Department of Physiology, Medical College, University of South China

⁰