The effects of pervanadate given at different times on the proliferation of irradiated NFS-60 cells

WANG Yuan; YUAN Xiaoling; ZHAO Zhenhu; SHAN Yajun; CHEN Jiapei; Cong Yuwen

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The effects of pervanadate given at different times on the proliferation of irradiated NFS-60 cells

更新时间：2023-03-30

- The effects of pervanadate given at different times on the proliferation of irradiated NFS-60 cells
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 3, Pages: 157-160(2004)
- 作者机构：
  
  1.甘肃省辐射环境监测站　兰州　730030
  2.军事医学科学院放射医学研究所　北京　100850
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WANG Yuan, YUAN Xiaoling, ZHAO Zhenhu, et al. The effects of pervanadate given at different times on the proliferation of irradiated NFS-60 cells. [J]. Journal of Radiation Research and Radiation Processing 22(3):157-160(2004)
DOI：

WANG Yuan, YUAN Xiaoling, ZHAO Zhenhu, et al. The effects of pervanadate given at different times on the proliferation of irradiated NFS-60 cells. [J]. Journal of Radiation Research and Radiation Processing 22(3):157-160(2004) DOI：

摘要

为了解酪氨酸磷酸酶抑制剂过钒酸钠用于辐射损伤治疗的可行性，并探讨酪氨酸磷酸酶在造血细胞辐射损伤中的作用，应用四甲基氮唑蓝（MTT）法观察了过钒酸钠不同给药方式对不同剂量照射NFS-60细胞增殖的影响。结果显示，过钒酸钠可特异地促进照射细胞的增殖，其促增殖作用随着照射剂量的增加而显著；并因过钒酸钠给药方式的不同而各异。对于3Gy照射NFS-60细胞，过钒酸钠以照射后24h给药效果最好，照射前给药与照射后即刻给药差异不明显，而对于5Gy照射细胞，过钒酸钠的最佳给药时间为照射后24和48h，照射前给药优于照射后即刻给药。酪氨酸磷酸酶可能参与造血细胞辐射损伤的进程，应用其抑制剂增强受体信号转导有希望成为放射病治疗研究的新方向。

Abstract

To comprehend the feasibility of the inhibitor of tyrosine phosphatase pervanadate using for therapy of radiation injury and inquire into the effects of tyrosine phosphatases on the radiation injury of hematopoietic cells, the effects of different times of administration on NFS-60 cells irradiated with different doses were observed. It was found that pervanadate could specifically enhance the proliferation of irradiated cells, such effects became obvious with the dose of irradiation increased and displayed time effects. For 3Gy irradiated NFS-60 cells, good results were achieved when pervanadate was administrated 24h after irradiation, there were no difference between before and 30 mins after irradiation, but for 5Gy irradiated cells, the best time administration is 24 and 48h after irradiation. Effects of pervanadate administrated before irradiation was better than that administrated 30min after irradiation. These results suggest that protein tyrosine phosphatase might involve in the course of radiation injury of hematopoietic cells. It is hoped that enhancing receptor signal transduction by PTP inhibitors will become a new way of therapy of acute radiation disease.

关键词

过钒酸钠辐射增殖NFS-60细胞

Keywords

PervanadateRadiationProliferationNFS-60 cells

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