Synthesis of thermoreversible and biodegradable PLGA-PEG-PLGA triblock copolymers and their molecular weight variation under irradiation

LIU Zhaomin; CHANG Liang; QIN Li

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Synthesis of thermoreversible and biodegradable PLGA-PEG-PLGA triblock copolymers and their molecular weight variation under irradiation

更新时间：2023-03-30

- Synthesis of thermoreversible and biodegradable PLGA-PEG-PLGA triblock copolymers and their molecular weight variation under irradiation
- Journal of Radiation Research and Radiation Processing Vol. 24, Issue 6, Pages: 351-355(2006)
- 作者机构：
  
  1.上海大学射线应用研究所　上海　201800
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LIU Zhaomin, CHANG Liang, QIN Li. Synthesis of thermoreversible and biodegradable PLGA-PEG-PLGA triblock copolymers and their molecular weight variation under irradiation. [J]. Journal of Radiation Research and Radiation Processing 24(6):351-355(2006)
DOI：

LIU Zhaomin, CHANG Liang, QIN Li. Synthesis of thermoreversible and biodegradable PLGA-PEG-PLGA triblock copolymers and their molecular weight variation under irradiation. [J]. Journal of Radiation Research and Radiation Processing 24(6):351-355(2006) DOI：

摘要

合成了不同嵌段的可降解的温敏型聚乙交酯丙交酯-聚乙二醇-聚乙交酯丙交酯共聚物（DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide，PLGA-PEG-PLGA）。用红外、核磁共振、凝胶渗透色谱等表征了其化学结构、分子量及分子量分布，研究了其相变过程。用辐照法成功地进行了PLGA-PEG-PLGA分子量调整。实验结果表明，在反应温度150℃催化剂辛酸亚锡0.04g反应8h，5.08g乙交酯与12.61g丙交酯（摩尔比为1∶2）的条件下，产物溶于水后得到的水凝胶具有明显的相变过程。不同分子量的共聚物相变温度不同，在固定聚乙二醇分子量且共聚物溶液浓度相同条件下，共聚物中丙交酯与乙交酯比例越高，共聚物分子量越大，相同浓度下的分子量越大的共聚物形成的溶胶-凝胶转变温度越低，凝胶-溶胶转变温度越高。当辐照20kGy样品的分子量分布最大，从而改变凝胶的相变温度。

Abstract

PLGA-PEG-PLGA triblock copolymer were synthesised with different compositions. Structure and molecular weight of the copolymer were characterized by FTIR,1,H-NMR and GPC. Phase diagram of the copolymer and their molecular weight variation under E-beam irradiation were studied. The results showed gelation of the copolymer synthesized in 8h at 150℃ with 0.04g catalyst, 5.08g glycolide, and 12.61g DL-lactide (molar ratio 1:2) had sharp sol-gel phase transition. In an aqueous solution of defined concentration of the copolymer with PEG of fixed molecular weight, by increaseing the DLLA/LA ratio and molecular weight of the copolymer, the temperature of sol-gel phase transition decreased, while the temperature of gel-sol phase transition increased. Maximum polydispersity could be achieved by irradiating the copolymer to 20kGy.

关键词

嵌段共聚物水凝胶生物降解性温敏性相变辐照

Keywords

Block copolymerAqueous gelaBiodegradableThermoreversiblePhase transitionIrradiation

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