EFFECT OF γ-RAYS IRRADIATION ON EXPRESSION OF CD3, CD4, CD8, B7.1 MOLECULES IN HUMAN LYMPHOCYTES*

ZHOU Jianhua; SU Liaoyuan; TONG Jian

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EFFECT OF γ-RAYS IRRADIATION ON EXPRESSION OF CD3, CD4, CD8, B7.1 MOLECULES IN HUMAN LYMPHOCYTES*

更新时间：2023-04-07

- EFFECT OF γ-RAYS IRRADIATION ON EXPRESSION OF CD3, CD4, CD8, B7.1 MOLECULES IN HUMAN LYMPHOCYTES*
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 2, Pages: 129-132(2000)
- 作者机构：
  
  1.苏州医学院放射医学系　苏州　215007
- 作者简介：
- 基金信息：
  
  Doctor study fund of Suzhou Medical College
- DOI：
  CLC：
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ZHOU Jianhua, SU Liaoyuan, TONG Jian. EFFECT OF γ-RAYS IRRADIATION ON EXPRESSION OF CD3, CD4, CD8, B7.1 MOLECULES IN HUMAN LYMPHOCYTES*. [J]. Journal of Radiation Research and Radiation Processing 18(2):129-132(2000)
DOI：

ZHOU Jianhua, SU Liaoyuan, TONG Jian. EFFECT OF γ-RAYS IRRADIATION ON EXPRESSION OF CD3, CD4, CD8, B7.1 MOLECULES IN HUMAN LYMPHOCYTES*. [J]. Journal of Radiation Research and Radiation Processing 18(2):129-132(2000) DOI：

摘要

用间接免疫荧光–流式细胞仪测定方法，观察,γ,射线对人淋巴细胞CD3、CD4、CD8、B7.1分子表达的影响。结果表明：高剂量,γ,射线影响CD3、CD4、CD8分子的表达，预先给予低剂量γ射线，再接受高剂量照射，可减少这种影响。,γ,射线能激活静止的淋巴细胞表达B7.1分子。

Abstract

The effects of γ-rays irradiation on CD3, CD4, CD8, B7.1 molecules expression of human lymphocytes which were irradiated with 0.5, 2, 4 and 8Gy γ-rays or with 0.5, 2, 4 and 8Gy (,D,2,) γ-rays 4h after 10cGy irradiation ,(D,1,), were investigated in normal donor. 24h or 48h after final irradiation the changes of CD3,+, CD4,+, CD8,+, B7.1,+, molecules were measured by flow cytometry(FCM) with immunofluorescence technique. The results showed that the CD3,+, CD4,+, CD8,+, molecules expression in the highly irradiated groups decreased with dose increase, while the CD3,+, CD4,+, CD8,+, molecules privously exposed to 10cGy irradiation could reduce this influence, and the B7.1,+, molecule expression in the high dose irradiation groups was enhanced with increasing dose.

关键词

γ射线CD3、CD4、CD8、B7.1分子表达

Keywords

γ-rayCD3 CD4 CD8 B7.1 molecule expression

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