EFFECT OF WHOLE BODY IRRADIATION WITH LOW DOSE X-RAYS ON EXPRESSION OF GLUCOCORTICOID RECEPTOR IN MOUSE SPLENOCYTES

LUO Can; FU Shibo; JU Guizhi

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EFFECT OF WHOLE BODY IRRADIATION WITH LOW DOSE X-RAYS ON EXPRESSION OF GLUCOCORTICOID RECEPTOR IN MOUSE SPLENOCYTES

更新时间：2023-04-07

- EFFECT OF WHOLE BODY IRRADIATION WITH LOW DOSE X-RAYS ON EXPRESSION OF GLUCOCORTICOID RECEPTOR IN MOUSE SPLENOCYTES
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 3, Pages: 232-235(2000)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物学重点实验室　长春　130021
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LUO Can, FU Shibo, JU Guizhi. EFFECT OF WHOLE BODY IRRADIATION WITH LOW DOSE X-RAYS ON EXPRESSION OF GLUCOCORTICOID RECEPTOR IN MOUSE SPLENOCYTES. [J]. Journal of Radiation Research and Radiation Processing 18(3):232-235(2000)
DOI：

LUO Can, FU Shibo, JU Guizhi. EFFECT OF WHOLE BODY IRRADIATION WITH LOW DOSE X-RAYS ON EXPRESSION OF GLUCOCORTICOID RECEPTOR IN MOUSE SPLENOCYTES. [J]. Journal of Radiation Research and Radiation Processing 18(3):232-235(2000) DOI：

摘要

采用放射性配体结合法，观察了不同低剂量X射线全身照射对小鼠脾细胞糖皮质激素受体（GCR）表达的影响及75mGy全身照射后GCR表达的时程变化。结果显示，25、50、75mGy X射线全身照射后8h小鼠脾细胞GCR表达明显下降；75mGy X射线全身照射后4h GCR表达开始下降，8hGCR表达显著低于对照组。低剂量X射线全身照射可降低小鼠脾细胞GCR的表达，提示GCR表达下调可能在低剂量辐射免疫增强效应中发挥作用。

Abstract

In this study, the effect of whole body irradiation (WBI) with different low doses of X-rays on the expression of Glucocorticoid receptor (GCR) in mouse splenocytes and the time course of GCR expression after WBI with 75mGy X-rays were observed using the radioactive ligand binding assay. Results showed that the GCR expression in mouse splenocytes decreased significantly 8h after WBI with 25, 50 and 75mGy X-ray irradiation, and in the case of 75mGy, the GCR expression began to decrease 4h after irradiation. Based on the fact that WBI with low doses of X-rays could reduce GCR expression in mouse splenocytes, it suggested that the down-regulated GCR expression may play a role in the enhancement of immune effect caused by low dose radiation.

关键词

糖皮质激素受体脾细胞X射线低剂量辐射

Keywords

GCRSplenocytesX-raysLow dose radiation

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