CHANGES IN TUMOR NECROSIS FACTOR α (TNFα) EXPRESSION IN MOUSE PERITONEAL MACROPHAGES AFTER WHOLE BODY X-RAY IRRADIATION

SUN Yimin; LIU Shuzheng

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CHANGES IN TUMOR NECROSIS FACTOR α (TNFα) EXPRESSION IN MOUSE PERITONEAL MACROPHAGES AFTER WHOLE BODY X-RAY IRRADIATION

更新时间：2023-04-07

- CHANGES IN TUMOR NECROSIS FACTOR α (TNFα) EXPRESSION IN MOUSE PERITONEAL MACROPHAGES AFTER WHOLE BODY X-RAY IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 3, Pages: 236-239(2000)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物学重点实验室　长春　130021
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation of China(39570188)
- DOI：
  CLC：
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SUN Yimin, LIU Shuzheng. CHANGES IN TUMOR NECROSIS FACTOR α (TNFα) EXPRESSION IN MOUSE PERITONEAL MACROPHAGES AFTER WHOLE BODY X-RAY IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 18(3):236-239(2000)
DOI：

SUN Yimin, LIU Shuzheng. CHANGES IN TUMOR NECROSIS FACTOR α (TNFα) EXPRESSION IN MOUSE PERITONEAL MACROPHAGES AFTER WHOLE BODY X-RAY IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 18(3):236-239(2000) DOI：

摘要

用L929细胞染料摄入法检测了小鼠受不同剂量（75mGy, 2.0Gy）X射线全身照射后小鼠腹腔巨噬细胞肿瘤坏死因子α（TNFα）表达量的时程变化及全身照射后24h的剂量–效应关系。结果可见，75mGy照射后3h, TNFα表达量有所增加，从6～120h，均显著高于对照组，12h表达量最高；2.0Gy照射后3～120h，不同时间点均显著高于对照，表达量最高点为12h。从剂量–效应关系中可见，经50mGy～2.0Gy不同剂量照射后，TNFα表达量均显著高于对照组，0.5Gy照射组其表达量最高，而经4.0Gy和6.0Gy照射后，TNFα的表达量显著低于对照组。提示一定剂量电离辐射可诱导巨噬细胞产生TNFα。

Abstract

The TNF-mediated L929 cell toxicity bioassay was used to examine the expression of TNFα in mouse peritoneal macrophages following whole body irradiation (WBI). The expression of TNFα gradually increased after WBI with 0.075Gy, reaching its peak at 12h. The TNFα expression of TNFα gradually increased from 3 to 120h after WBI with 2Gy. The expression of TNFα was significantly increased at 24h after WBI with 0.05, 0.075, 0.1. 0.2, 0.5, 1.0 and 2.0Gy.The expression of TNFα increased most markedly in the group irradiated with 0.5Gy.

关键词

X线辐射腹腔巨噬细胞肿瘤坏死因子α

Keywords

X-ray irradiationPeritoneal macrophagesTumor necrosis facfor α

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