THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION

ZENG Guiying; TIAN Furong; CHEN Yongbin; REN Dongqing; CUI Daxiang

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THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION

更新时间：2023-04-07

- THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 19, Issue 1, Pages: 59-61(2001)
- 作者机构：
  
  1.第四军医大学放射医学教研室　西安　710032
  2.第四军医大学全军基因诊断技术研究所　西安　710032
- 作者简介：
- 基金信息：
  
  第四军医大学211工程专项基金(98X207)
- DOI：
  CLC：
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ZENG Guiying, TIAN Furong, CHEN Yongbin, et al. THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 19(1):59-61(2001)
DOI：

ZENG Guiying, TIAN Furong, CHEN Yongbin, et al. THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 19(1):59-61(2001) DOI：

摘要

用不同剂量的,60,Co γ射线照射BALB/c小鼠的全身或腹部，于照射后1—3h内注入同系正常小鼠小肠RNA，通过肠腺存活率的测定，观察小肠RNA显效时间和照射方式对其修复作用的影响。结果表明，（1）小鼠受照射后6h空肠肠腺存活率即开始降低，4d时降至最低值；（2）受腹部照射小鼠在小肠RNA注入后6h肠腺存活率比照射对照组提高21.40%;（3）正常小鼠小肠RNA在促进受全身照射小鼠十二指肠、空肠和回肠恢复时的DMF（Dose Modifying Factor）分别为1.17、1.12、1.10。结果说明，小肠RNA不仅可提高受腹部照射同系小鼠空肠肠腺存活率，而且也可提高受全身照射同系小鼠十二指肠、空肠和回肠的肠腺存活率，并在注入后6h即可表现出来。

Abstract

Mouse intestinal RNA was injected into the mice of the same strain within 1—3h after different doses of abdominal or whole body ,60,Co ,γ, irradiation,so as to explore the initial effective time of mouse intestinal RNA and the affection of radiation condition on its restorative effect, by measuring the survival of mouse intestinal crypt. The results showed (1) A decrease in the survival of mouse intestinal crypt began 6h after the irradiation,and the lowest survival rate appeared on the fourth day.(2) The survival of mouse intestinal crypt of the abdominal irradiated mice increased 21.4% at 6h after intestinal RNA injection as compared with that of the irradiated control group.(3) The dose modifying factor (DMF) of normal mouse intestinal RNA in the promotion of the recovery of the duodenum, jejunum and ileum of mice after whde body irradiation 1.17, 1.12 and 1.10 respectively. The above results suggest that mouse intestinal RNA can raise not only the survival of jejunum crypt of the mice of the same strain after abdominal irradiation but also the survival of crypt of the duodenum, jejunum and ileum of the mouse after whole body irradiation, which may be observed 6h after the irradiation.

关键词

小肠RNAγ射线小鼠肠腺存活率

Keywords

Intestinal RNAγ rayMouseSurvuval of mouse crypt

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