EFFECTS OF E838 ON THE SURVIVAL AND HEMATOPOIETIC FUNCTION OF RADIATION INJURED MICE

GUO Chaohua; ZHOU Jianjun; HU Hualing; KONG Peiyan; ZOU Zhongmin; ZHOU Yanhong; RAN Xinze; SU Yongping; LUO Chengji

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EFFECTS OF E838 ON THE SURVIVAL AND HEMATOPOIETIC FUNCTION OF RADIATION INJURED MICE

更新时间：2023-04-07

- EFFECTS OF E838 ON THE SURVIVAL AND HEMATOPOIETIC FUNCTION OF RADIATION INJURED MICE
- Journal of Radiation Research and Radiation Processing Vol. 19, Issue 4, Pages: 279-282(2001)
- 作者机构：
  
  1.第三军医大学防原医学教研室、全军复合伤研究所　重庆　400038
  2.重庆市沙区第三人民医院　重庆　400038
  3.第三军医大学新桥医院血液内科　重庆　400038
- 作者简介：
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GUO Chaohua, ZHOU Jianjun, HU Hualing, et al. EFFECTS OF E838 ON THE SURVIVAL AND HEMATOPOIETIC FUNCTION OF RADIATION INJURED MICE. [J]. Journal of Radiation Research and Radiation Processing 19(4):279-282(2001)
DOI：

GUO Chaohua, ZHOU Jianjun, HU Hualing, et al. EFFECTS OF E838 ON THE SURVIVAL AND HEMATOPOIETIC FUNCTION OF RADIATION INJURED MICE. [J]. Journal of Radiation Research and Radiation Processing 19(4):279-282(2001) DOI：

摘要

动物照射前后不同时间给予新型抗放药E838腹腔注射，观察其死亡率和死亡动物活存时间，并在用药后不同时间检测其外周血白细胞数、骨髓有核细胞数、骨髓粒系祖细胞集落形成单位CFU—GM和造血干细胞CFU—S数，研究了E838对放射损伤小鼠存活及造血功能的影响。结果表明，E838预防用药能够明显提高损伤动物的30d存活率及平均活存时间，对造血功能的研究结果也表明，E838预防用药能够减少损伤后外周血白细胞数、骨髓有核细胞数、骨髓粒—单系祖细胞数及造血干细胞CFU—S数的下降幅度。显示出E838对放射损伤具有确切的预防效果，对损伤小鼠造血功能也有明显的保护作用。

Abstract

To study the effects of radioprotectant—E838 on irradiated mice. Irradiated mice were injected intraperitoneally with E838 before and after irradiation. Then, the survival rate and the average living days of dead animals were calculated Meanwhile the peripheral blood WBC, bone marrow nucleate cells,CFU—GM and CFU—S were analysed. When used before irradiation, E838 could significantly increase the suvival rate and the average survival days of dead animals, and reduce the damage of the hematopoietic system. The results show that E838 has a good preventing effect on radiation injury.

关键词

E838放射损伤造血功能

Keywords

E838Radiation injuryHemapoiecsis

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Institute of Radiation Medicine, CAMS

1(Department of Radioxicolog, Schoolof RadiationMedicine & Protection, University of Soochow,,)

2(Department of Oncology, the First Peoples' Hospital of Zhangjiagang, Zhangjiagang ,)

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