THE PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN GLUTATHIONE CONTENT IN HUMAN SGC7901 CELL LINE PRETREATED WITH RADIOSENSITIZER AND ITS SUFFERED RADIATION DOSE

KONG Zhaolu; JIN Yizun; SHEN Zhifen

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THE PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN GLUTATHIONE CONTENT IN HUMAN SGC7901 CELL LINE PRETREATED WITH RADIOSENSITIZER AND ITS SUFFERED RADIATION DOSE

更新时间：2023-04-07

- THE PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN GLUTATHIONE CONTENT IN HUMAN SGC7901 CELL LINE PRETREATED WITH RADIOSENSITIZER AND ITS SUFFERED RADIATION DOSE
- Journal of Radiation Research and Radiation Processing Vol. 20, Issue 3, Pages: 216-219(2002)
- 作者机构：
  
  1.复旦大学放射医学研究所　上海　200032
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KONG Zhaolu, JIN Yizun, SHEN Zhifen. THE PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN GLUTATHIONE CONTENT IN HUMAN SGC7901 CELL LINE PRETREATED WITH RADIOSENSITIZER AND ITS SUFFERED RADIATION DOSE. [J]. Journal of Radiation Research and Radiation Processing 20(3):216-219(2002)
DOI：

KONG Zhaolu, JIN Yizun, SHEN Zhifen. THE PRELIMINARY STUDY OF THE RELATIONSHIP BETWEEN GLUTATHIONE CONTENT IN HUMAN SGC7901 CELL LINE PRETREATED WITH RADIOSENSITIZER AND ITS SUFFERED RADIATION DOSE. [J]. Journal of Radiation Research and Radiation Processing 20(3):216-219(2002) DOI：

摘要

研究了辐射增敏剂丁胱亚磺酰亚胺（BSO）作用下胃腺癌细胞（SGC）内谷胱甘肽（GSH）含量与照射剂量间的关系。实验观察到胃癌细胞内GSH含量有呈照射剂量依赖性升高的趋势，而用BSO预处理后的细胞，GSH含量迅速降低且变化不受照射剂量的影响。

Abstract

In this paper, the change of glutathione (GSH) content in the X ray irradiated human stomach cancer cell line SGC7901 which were pretreated with buthionine sulfoximine(BSO) were studied. The results showed that the GSH content in these cells decreased rapidly and the change was independent to the radiation dose. On the contrary, there was a trend for the un—pretreated control cells that the GSH level in the cancer cells rose alone with the increase of radiation dose.

关键词

谷胱甘肽照射丁胱亚磺酰亚胺γ谷氨酰半胱氨酸合成酶

Keywords

GlutathioneIrradiationButhionine sulfoximineγ glutamylcysteine synthetase

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