DNA SINGLE AND DOUBLE STRAND BREAKS OF PERIPHERAL BLOOD LYMPHOCYTES IN MICE INDUCED BY γ RAYS IRRADIATION

ZHANG Junning; HONG Chengjiao; ZHU Shoupeng

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DNA SINGLE AND DOUBLE STRAND BREAKS OF PERIPHERAL BLOOD LYMPHOCYTES IN MICE INDUCED BY γ RAYS IRRADIATION

更新时间：2023-04-07

- DNA SINGLE AND DOUBLE STRAND BREAKS OF PERIPHERAL BLOOD LYMPHOCYTES IN MICE INDUCED BY γ RAYS IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 20, Issue 3, Pages: 220-224(2002)
- 作者机构：
  
  1.苏州大学附属第一医院　苏州　215006
  2.苏州大学核医学院　苏州　215007
- 作者简介：
- 基金信息：
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ZHANG Junning, HONG Chengjiao, ZHU Shoupeng. DNA SINGLE AND DOUBLE STRAND BREAKS OF PERIPHERAL BLOOD LYMPHOCYTES IN MICE INDUCED BY γ RAYS IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 20(3):220-224(2002)
DOI：

ZHANG Junning, HONG Chengjiao, ZHU Shoupeng. DNA SINGLE AND DOUBLE STRAND BREAKS OF PERIPHERAL BLOOD LYMPHOCYTES IN MICE INDUCED BY γ RAYS IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 20(3):220-224(2002) DOI：

摘要

分别应用中性单细胞凝胶电泳、碱性单细胞凝胶电泳技术检测了不同剂量γ射线外照射对小鼠外周血淋巴细胞DNA的损伤。结果表明，γ射线外照射对小鼠外周血淋巴细胞DNA具有明显的损伤作用，彗星细胞百分率显著增加，DNA电泳迁移，且迁移的距离与照射剂量之间呈良好的线性关系。

Abstract

DNA single — and double — strand breaks of peripheral blood lymphocytes in mice induced by γ rays irradiation were detected by neutral and alkaline comet assay. The results indicated that γ rays caused the increase of DNA migration length in the lymphocytes in a dose —dependent manner. It should be noted that comet assay can be applied not only to monitor DNA single and double strand breaks in vivo or in vitro,but also to serve as a new biological dosimeter.

关键词

中性单细胞凝胶电泳DNA双链断裂碱性单细胞凝胶电泳DNA单链断裂淋巴细胞γ射线照射

Keywords

Neutral comet assayDNA double strand breaksAlkaline comet assayDNA single strand breaksLymphocytesγ rays irradiation

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