A RESEARCH ON THE KINETIC MECHANISM OF MICRONUCLEI FORMATION

Wang Tianyu; Yang Lijun; Huang Qingtian

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A RESEARCH ON THE KINETIC MECHANISM OF MICRONUCLEI FORMATION

更新时间：2023-04-18

- A RESEARCH ON THE KINETIC MECHANISM OF MICRONUCLEI FORMATION
- Journal of Radiation Research and Radiation Processing Vol. 1, Issue 1, Pages: 64-68(1983)
- 作者机构：
  
  1.南京医学院
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Wang Tianyu, Yang Lijun, Huang Qingtian. A RESEARCH ON THE KINETIC MECHANISM OF MICRONUCLEI FORMATION. [J]. Journal of Radiation Research and Radiation Processing 1(1):64-68(1983)
DOI：

Wang Tianyu, Yang Lijun, Huang Qingtian. A RESEARCH ON THE KINETIC MECHANISM OF MICRONUCLEI FORMATION. [J]. Journal of Radiation Research and Radiation Processing 1(1):64-68(1983) DOI：

摘要

本文基于实验资料及其统计分析提出：辐照后经培养的淋巴细胞中，可见到几及主核1/3～1/2大小的细胞微核，这并非单纯地由所谓的染色体断片形成，而是由发生畸变的染色体部分（诸如无着丝粒环、微小体、染色体断片、甚至包括带着丝粒的畸变染色体等），于胞质中在不同状态、不同条件下融合（如DNA的交联等）的结果。这种融合过程受着细胞核膜膜性结构的直接作用和细胞生化动力学的调节控制。本文提出：由融合机理形成细胞微核的途径是一个不可忽视的重要方面。

Abstract

Based on the detailed experimental record and the statistical analysis of the data, we wish to put forward our concept on the micronuclei formation as follows: After irradiation the micronuclei were visible in the lymphocyte, their size is 1/3~1/2 of the main nuclei. The micronuclei were not derived solely from the fractions of the chromosome, but from the various components of the chromosome (such as acentric rings, microbodies, acentric fragments, various chromosome-containing mitosomes etc.) by fusing at various states and conditions in the cell plasma. Factors influencing the process of fusion include the allosteric change in membrane configuration of nuclei and of the kinetic status of the cell. According to the characteristic helical structure of DNA polynucleotide chain, we believe that under irradiation the acentric fragments of the double-nuclei lymphocyte showed a tendency to fuse leading to the formation of micronuclei. The way of micronuclei formation through fusion mechanism may be one of the main probabilities.

关键词

淋巴细胞微核形成动力学机理膜性结构融合

Keywords

Lymphocytemicronuclei formationkinetic mechanismmembrane configurationfusion

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