THE STUDY OF RADIOSENSITIVITY OF MOUSE L7712 LEUKEMIC CELLS IRRADIATED BY THREE KINDS OF LOW LET RADIATIONS

Lin Wanmin; Ma Chengwu; Luo Zuyu

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THE STUDY OF RADIOSENSITIVITY OF MOUSE L7712 LEUKEMIC CELLS IRRADIATED BY THREE KINDS OF LOW LET RADIATIONS

更新时间：2023-04-18

- THE STUDY OF RADIOSENSITIVITY OF MOUSE L7712 LEUKEMIC CELLS IRRADIATED BY THREE KINDS OF LOW LET RADIATIONS
- Journal of Radiation Research and Radiation Processing Vol. 1, Issue 1, Pages: 74-79(1983)
- 作者机构：
  
  1.复旦大学
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Lin Wanmin, Ma Chengwu, Luo Zuyu. THE STUDY OF RADIOSENSITIVITY OF MOUSE L7712 LEUKEMIC CELLS IRRADIATED BY THREE KINDS OF LOW LET RADIATIONS. [J]. Journal of Radiation Research and Radiation Processing 1(1):74-79(1983)
DOI：

Lin Wanmin, Ma Chengwu, Luo Zuyu. THE STUDY OF RADIOSENSITIVITY OF MOUSE L7712 LEUKEMIC CELLS IRRADIATED BY THREE KINDS OF LOW LET RADIATIONS. [J]. Journal of Radiation Research and Radiation Processing 1(1):74-79(1983) DOI：

摘要

运用琼脂扩散盒（ADC）培养细胞集落的方法，我们比较了用三种低LET射线——200kV X射线、,60,Co γ射线和20MeV电子束，在两个剂量率（0.35Gy/min和1Gy/min）下，照射淋巴型白血病细胞L7712得到的存活曲线。,细胞在615近交系小鼠和昆明种小白鼠腹腔中的扩散盒中均生长良好。每个扩散盒中植入的细胞数，和细胞集落数的关系呈线性，在两组数据中无明显差异.,研究了200kV X射线对细胞的辐照效应。剂量率为0.35Gy/min时，存活曲线的,D,0,=1.55（1.45～1.67）Gy，,n,为0.94（0.88～1.03），相关系数,r,=-0.88。而剂量率在1.0Gy/min时，,D,0,和,n,分别为1.39（1.30～1.54）Gy和0.90（0.82～1.0），相关系数,r,=-0.85。受,60,Co γ射线（0.35Gy/min）照射后，,D,0,、,n,和,r,分别为1.76（1.60～1.90）Gy，0.96（0.87～1.07）和-0.82。,60,Co γ射线和200kV X射线相比得到的相对生物学效应（RBE）为0.88。20MeV电子束（1.0Gy/min）照后的存活曲线，其,D,0,和,n,分别为1.96（1.87～2.07）Gy，0.99（0.94～1.05），,r,=-0.93。与200kV X射线相比，RBE等于0.71。

Abstract

Using the agar diffusion chamber (ADC) for colony formation of lymphocytic leukemic cells L7712, we compared the survival curves of the cells irradiated by three kinds of low LET radiations — 200kV x-rays,60,Co gamma rays and 20 MeV electron beam in two rates (0.35Gy/min and 1.0Gy/min).,The cells grew well in ADC both in the peritoneums of 615 inbred mice and Kumming white mice. The relationship between the number of cells implanted to each chamber and the number of colonies formed was shown to be linear. There was no significant difference between the two sets of data.,200kV x-rays irradiation to cells was studied. The survival curve for a dose rate of 0.35Gy/min had a ,D,0, of 1.55(1.45~1.67)Gy,n, of 0 94(0.88~1.03) and correlation coefficient ,r,= -0.88; while with a dose rate of 1.0Gy/min they were 1.39(1.30—1.54)Gy, 0.90(0.82~1.0) and -0.85 respectively. The ,D,0,n, and ,r, for survival curve after ,60,Co irradiation (0.35Gy/min) were 1.76(1.60 ~1.90)Gy, 0.96(0.87~1.07) and -0.82. The RBE of ,60,Co gamma rays as compared with 200kV x-rays was 0.88. The survival curve for 20MeV electron beam (1.0Gy/min) had a ,D,0, of 1.96(1.87~2.07)Gy and ,n, of 0.99 (0.94~1.05),r,=-0.93. Its RBE as compared with 200kV x-rays was 0 71.

关键词

扩散盒细胞集落形成效率存活曲线低LET辐照剂量率相对生物学效应平均致死剂量外推值n

Keywords

Agar diffusion chamberClonogenic efficiencySurvival curveLow LET radiationDose rateRelative Biological Effectiveness (RBE)Mean lethal does (D0)Extrapolation number (n)

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