THE RESTORATIVE EFFECT OF FOUR KINDS OF NUCLEIC ACID PRECURSOR ON THE SMALL INTESTINE OF MICE AFTER WHOLE-BODY γ-IRRADIATION

Zeng Guiying; Xie Xuejun; Tian Furong; Zhou Yuankai

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THE RESTORATIVE EFFECT OF FOUR KINDS OF NUCLEIC ACID PRECURSOR ON THE SMALL INTESTINE OF MICE AFTER WHOLE-BODY γ-IRRADIATION

更新时间：2023-04-18

- THE RESTORATIVE EFFECT OF FOUR KINDS OF NUCLEIC ACID PRECURSOR ON THE SMALL INTESTINE OF MICE AFTER WHOLE-BODY γ-IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 4, Pages: 231-233(1998)
- 作者机构：
  
  1.第四军医大学防原医学教研室　西安　710032
- 作者简介：
- 基金信息：
  
  Science Foundation of Fourth Millitary Medical University
- DOI：
  CLC：
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Zeng Guiying, Xie Xuejun, Tian Furong, et al. THE RESTORATIVE EFFECT OF FOUR KINDS OF NUCLEIC ACID PRECURSOR ON THE SMALL INTESTINE OF MICE AFTER WHOLE-BODY γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 16(4):231-233(1998)
DOI：

Zeng Guiying, Xie Xuejun, Tian Furong, et al. THE RESTORATIVE EFFECT OF FOUR KINDS OF NUCLEIC ACID PRECURSOR ON THE SMALL INTESTINE OF MICE AFTER WHOLE-BODY γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 16(4):231-233(1998) DOI：

摘要

BALB/c小鼠接受1050cGy ,60,Co γ射线全身照射后1h内肌肉注射四种核酸前体（ATP、GMP、Ad,enine、Thymine,）中的一种，可以提高十二指肠、空肠及回肠的肠腺存活率约20%,小肠的大体观察也较为正常。综合本文及作者以前的实验结果，认为核酸及其前体可用于大剂量电离辐射照射后引起的肠道辐射损伤的综合治疗。

Abstract

Four kinds of nucleic acid precursor (ATP,GMP,Adenine,Thymine) were injected intramuscularly into mice within 1h after 1050cGy whole-body γ-irradiation. Four days later,the mice were sacrificed and about 2cm long segment of duodenum, jejunum and ileum were dissected respectively for crypt survival assay using the technique of crypt counting per unit area. The results indicated that about 20% increase in crypt survival has been observed at each intestinal segment of mice receiving the nucleic acid precursor injection as compared with that of irradiated control. Meanwhile,the gross appearance of the samll intestine looks comparatively normal as well. From the results obtained both in this paper and in our previously published papers, which have been listed in detail in this paper, we propose that the nucleic acids (DNA,RNA) and its precursors (e.g. ATP, being used currently in clinical practice) can be used as one of the measures in the treatment of intestinal radiation damage induced by a large dose whole-body or abdominal irradiation.

关键词

电离辐射核酸前体小肠恢复作用

Keywords

Ionizing radiationNucleic acid precursorSmall intestineRestorative effect

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