EFFECT OF WR-2721 ON LIPID PEROXIDATION INDUCED BY IONIZING RADIATION Ⅱ. LIPID PEROXIDES IN SUBCELLULAR FRACTIONS OF LIVER AND BRAIN OF WHOLE-BODILY IRRADIATED MICE

Zhou Xun; Fang Yunzhong

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EFFECT OF WR-2721 ON LIPID PEROXIDATION INDUCED BY IONIZING RADIATION Ⅱ. LIPID PEROXIDES IN SUBCELLULAR FRACTIONS OF LIVER AND BRAIN OF WHOLE-BODILY IRRADIATED MICE

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- EFFECT OF WR-2721 ON LIPID PEROXIDATION INDUCED BY IONIZING RADIATION Ⅱ. LIPID PEROXIDES IN SUBCELLULAR FRACTIONS OF LIVER AND BRAIN OF WHOLE-BODILY IRRADIATED MICE
- Journal of Radiation Research and Radiation Processing Vol. 3, Issue 4, Pages: 24-28(1985)
- 作者机构：
  
  1.军事医学科学院放射医学研究所
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Zhou Xun, Fang Yunzhong. EFFECT OF WR-2721 ON LIPID PEROXIDATION INDUCED BY IONIZING RADIATION Ⅱ. LIPID PEROXIDES IN SUBCELLULAR FRACTIONS OF LIVER AND BRAIN OF WHOLE-BODILY IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 3(4):24-28(1985)
DOI：

Zhou Xun, Fang Yunzhong. EFFECT OF WR-2721 ON LIPID PEROXIDATION INDUCED BY IONIZING RADIATION Ⅱ. LIPID PEROXIDES IN SUBCELLULAR FRACTIONS OF LIVER AND BRAIN OF WHOLE-BODILY IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 3(4):24-28(1985) DOI：

摘要

小鼠经850 rad照射后第1、3、5、7和10天，肝与脑的亚细胞各部分脂类过氧化率均有不同程度的增高，如微粒体>线粒体>胞核。其峰值出现于照射后第3天或第5天。腹腔注射WR-2721可使照射后亚细胞各部分的脂类过氧化程度显著减轻。

Abstract

There was a variety of increasing rates of lipid peroxidation in subcellular fractions of liver and brain in mice on the 1st, 3rd, 5th, 7th and 10th day after the irradiation of 850 rad, as shown in the following sequence microsome>mitochondria>nucleus. The peak values appeared on the 3rd or 5th day. Intraperitoneal injection of WR-2721 gave an inhibitory effect on the LPO formation in subcellular fraction of liver and brain.

关键词

亚细胞器胞核线粒体微粒体多不饱和脂肪酸LPO

Keywords

Subcellular fractionMitochondriaMicrosomePolyunsaturated acidLPO(lipid peroxide)

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