THE STUDY OF SLOW RELEASE ANTICANCER DRUG PREPARED BY RADIATION COPOLYMERIZATION AT LOW TEMPERATURE

Li Ximing; Yuan Zhijian; Chen Wenming; Gu Baoming; Jiang Xintian

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THE STUDY OF SLOW RELEASE ANTICANCER DRUG PREPARED BY RADIATION COPOLYMERIZATION AT LOW TEMPERATURE

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- THE STUDY OF SLOW RELEASE ANTICANCER DRUG PREPARED BY RADIATION COPOLYMERIZATION AT LOW TEMPERATURE
- Journal of Radiation Research and Radiation Processing Vol. 7, Issue 3, Pages: 36-40,9(1989)
- 作者机构：
  
  1.中国科学技术大学，合肥
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Li Ximing, Yuan Zhijian, Chen Wenming, et al. THE STUDY OF SLOW RELEASE ANTICANCER DRUG PREPARED BY RADIATION COPOLYMERIZATION AT LOW TEMPERATURE. [J]. Journal of Radiation Research and Radiation Processing 7(3):36-40,9(1989)
DOI：

Li Ximing, Yuan Zhijian, Chen Wenming, et al. THE STUDY OF SLOW RELEASE ANTICANCER DRUG PREPARED BY RADIATION COPOLYMERIZATION AT LOW TEMPERATURE. [J]. Journal of Radiation Research and Radiation Processing 7(3):36-40,9(1989) DOI：

摘要

本文报告了甲基丙烯酸β-羟乙酯低温辐射聚合固定抗癌药物的研究结果。探讨了亲水性单体、疏水性单体、交联剂、辐射剂量以及聚合物结构、药物含量等因素对固定抗癌药物氟尿嘧啶释放速率的影响，研究发现氟尿嘧啶的释放遵从扩散机制，释放的质量分数（w）与释放时间（t）之间，有w∝t,0.5,的关系。对于丝裂霉素、平阳霉素等抗癌药物的慢释放体系也作了初步研究。

Abstract

The controlled release anticancer drug-copolymer composites were made by radiation-induced copolymerization at low temperature. The release rate and amount of drug can be controlled by regulating the content of bydrophilic or hydro phobic monomer and cross-linking reagent in drug-copolymer composite and by changing the radiation dose and drug content. The pore structure of composite may be promote the release rate. The diffuse mechanisms of drug were discussed.

关键词

抗癌剂辐射聚合慢释放药物

Keywords

Anticancer drugRadiation copolymerizationSlow release

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