RADIOSENSITIZATION OF AT2153 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1

Ma Chengwu; Xue Yongquan; Luo Zuyu

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RADIOSENSITIZATION OF AT2153 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1

更新时间：2023-04-23

- RADIOSENSITIZATION OF AT2153 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1
- Journal of Radiation Research and Radiation Processing Vol. 7, Issue 3, Pages: 41-44(1989)
- 作者机构：
  
  1.复旦大学，上海
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Ma Chengwu, Xue Yongquan, Luo Zuyu. RADIOSENSITIZATION OF AT2153 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1. [J]. Journal of Radiation Research and Radiation Processing 7(3):41-44(1989)
DOI：

Ma Chengwu, Xue Yongquan, Luo Zuyu. RADIOSENSITIZATION OF AT2153 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1. [J]. Journal of Radiation Research and Radiation Processing 7(3):41-44(1989) DOI：

摘要

一种属于哌嗪二酮类衍生物的抗癌新药—丙双吗啉（AT,2153,，MST,-02,）是由任云峰等,[1],合成的，它对多种肿瘤有显著作用，对小鼠肉瘤S,37,也有辐射增强作用。本工作利用细胞集落形成技术，研究丙双吗啉对乏氧条件下离体培养的人肺腺癌细胞系（SPC-A-1）的辐射增敏效应，在药物浓度为0.1 mmol dm,-3,时，增敏比（SER）为1.22，C,1.6,值为0.29 m mol•dm,-3,。丙双吗啉是一种具有潜在能力的辐射增敏剂。

Abstract

A new antitumour agent of diketopiperazine derivative, dl-1,2-bis(4-morpholinemethyl-3,5-dioxopiperazin-l-yl)propane (AT 2153, MST-02) was synthesized by Y. F. Ren et al,[1],. It exhibited significant activities against several kinds of cancer and radiopotentiating effect on Sarcoma S 37 in mice.,The radiosensitizing effect of AT 2153 was studied with hypoxic Human Lung Adeno-carcinoma cell line SPC-A-1 in vitro. Using colony-forming technique, its SER is 1.22 at the concentration of 0.10 m mol dm,-3, and the C 1.6 is 0.29 m mol dm,-3,. It might be a potent radiosensitizer.

关键词

哌嗪二酮类衍生物（AT 2153 MST-02）增敏比(SER）SPC-A-1细胞系集落形成技术

Keywords

Diketopiperazine derivative (AT 2153 MST-02)Sensitization enhancement ratio(SER)SPC-A-1 cell lineColony-forming technique

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