COMPARATIVE RETENTION OF FISSION FRAGMENT <sup>147</sup>Pm IN REGENERATED AND FETAL LIVER ON INDUCTION OF CHROMOSOME ABERRATIONS IN THESE CELLS

Zhu Shoupeng; Zheng Siying; Wang Liuyi; Yang Shujin

您当前的位置：

首页 >

文章列表页 >

COMPARATIVE RETENTION OF FISSION FRAGMENT ¹⁴⁷Pm IN REGENERATED AND FETAL LIVER ON INDUCTION OF CHROMOSOME ABERRATIONS IN THESE CELLS

更新时间：2023-04-23

- COMPARATIVE RETENTION OF FISSION FRAGMENT ¹⁴⁷Pm IN REGENERATED AND FETAL LIVER ON INDUCTION OF CHROMOSOME ABERRATIONS IN THESE CELLS
- Journal of Radiation Research and Radiation Processing Vol. 7, Issue 4, Pages: 19-24(1989)
- 作者机构：
  
  1.苏州医学院，苏州
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
Zhu Shoupeng, Zheng Siying, Wang Liuyi, et al. COMPARATIVE RETENTION OF FISSION FRAGMENT ¹⁴⁷Pm IN REGENERATED AND FETAL LIVER ON INDUCTION OF CHROMOSOME ABERRATIONS IN THESE CELLS. [J]. Journal of Radiation Research and Radiation Processing 7(4):19-24(1989)
DOI：

Zhu Shoupeng, Zheng Siying, Wang Liuyi, et al. COMPARATIVE RETENTION OF FISSION FRAGMENT ¹⁴⁷Pm IN REGENERATED AND FETAL LIVER ON INDUCTION OF CHROMOSOME ABERRATIONS IN THESE CELLS. [J]. Journal of Radiation Research and Radiation Processing 7(4):19-24(1989) DOI：

摘要

考虑到肝脏是,147,Pm污染早期滞留和作用的主要靶器官，本研究对,147,Pm在肝及胚肝中的滞留和诱发肝及胚肝细胞染色体畸变效应进行了对比观察。发现当,147,Pm摄入机体后，在再生肝中的滞留量要比在同期胚肝中高出700倍之多，估算在再生肝中的累积吸收剂量为2.87 Gy，而在胚肝中只有0.004 Gy。这与胎盘的屏障作用密切相关，起到了对胚胎细胞的保护作用。在此条件下,147,Pm诱发再生肝细胞的染色体畸变率为50.2%，而对胚肝细胞则为28.3%，二者之差不到一倍。由此可见胚肝细胞对,147,Pm的辐射敏感性要比再生肝细胞高得多。至于从,147,Pm对再生肝及胚肝细胞所诱发的染色体畸变类型来看，则都以染色单体型畸变为主。

Abstract

The purpose of the present study is to ascertain comparative retention of fission fragment ,147,Pm in regenerated and fetal liver on induction, of chromosome aberrations in these cells. The results indicated that retention of ,147,Pm in regenerated liver was about 700 times than in fetal liver. The cumulative absorption dose in regenerated liver was about 2.87Gy, while in fetal liver — only 0.004 Gy. Under the same conditions, the incidence rate of chromosome aberrations in regenerated liver cells induced by ,147,Pm was 50.2%, and in fetal liver cells — about 28.3%. It should be concluded that the radiosensitivity to ,147,Pm was not uniform among the regenerated and fetal liver cells. Our study suggested that fetal liver cells show to be more radiosensitive to ,147,Pm than regenerated liver cells. Among the type of aberrations in both cells induced by ,147,Pm, chromatid breakages were predominant, accompanied with a few chromosome breakages.

关键词

147Pm滞留再生肝细胞胚肝细胞突变效应

Keywords

147PmRetentionRegenerated liver cellsFetal liver cellsMutagenic effect

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

STUDY ON THE TRANSFERENCE AND RETENTION OF ⁷⁵Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS

TRANSFERENCE, RETENTION AS WELL AS DOSE-ESTIMATION OF ¹³⁴Cs IN THE RAT S WHOLE BODY, SKELETON AND TESTES

PROLIFERATION ABILITY ON BONE MARROW AND THYMUS CELLS OF RATS TREATED WITH LOW DOSES OF INTERNAL RADIATORS

SOME CHARACTERISTIC OF THE RETENTION, DISTRIBUTION AND INTERNAL DOSES OF ⁵⁹Fe IN RATS

ACCUMULATION OF RADIONUCLIDE ¹⁴⁷Pm IN SUBCELLULAR LEVEL BY ELECTRON MICROSCOPIC AUTORADIOGRAPHY

Related Author

No data

Related Institution

Departmet of Medical Radiobiology, Suzhou Medical College

Department of Medical Radiobiology, Suzhou Medical College

Institute of Naval Medical Research

⁰

COMPARATIVE RETENTION OF FISSION FRAGMENT 147Pm IN REGENERATED AND FETAL LIVER ON INDUCTION OF CHROMOSOME ABERRATIONS IN THESE CELLS

DOI：

摘要

Abstract

关键词

Keywords

references

COMPARATIVE RETENTION OF FISSION FRAGMENT ¹⁴⁷Pm IN REGENERATED AND FETAL LIVER ON INDUCTION OF CHROMOSOME ABERRATIONS IN THESE CELLS