DOMINANT LETHAL MUTATION IN MICE INDUCED BY LOW DOSE TRITIATED WATER

Jiang Tao; Zhou Xiangyan; Dong Jinchan; Wang Chunyan

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DOMINANT LETHAL MUTATION IN MICE INDUCED BY LOW DOSE TRITIATED WATER

更新时间：2023-04-23

- DOMINANT LETHAL MUTATION IN MICE INDUCED BY LOW DOSE TRITIATED WATER
- Journal of Radiation Research and Radiation Processing Vol. 10, Issue 3, Pages: 135-137(1992)
- 作者机构：
  
  1.卫生部工业卫生实验所，北京
- 作者简介：
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Jiang Tao, Zhou Xiangyan, Dong Jinchan, et al. DOMINANT LETHAL MUTATION IN MICE INDUCED BY LOW DOSE TRITIATED WATER. [J]. Journal of Radiation Research and Radiation Processing 10(3):135-137(1992)
DOI：

Jiang Tao, Zhou Xiangyan, Dong Jinchan, et al. DOMINANT LETHAL MUTATION IN MICE INDUCED BY LOW DOSE TRITIATED WATER. [J]. Journal of Radiation Research and Radiation Processing 10(3):135-137(1992) DOI：

摘要

本文报道了氚水,β,射线照射雄性小鼠诱发显性致死突变的研究结果。小鼠精细胞受照剂量为0.073—0.71 Gy时，与其交配后怀孕的正常雌鼠的植入后丢失率与受照剂量呈正相关的关系；显性致死突变率亦随着受照剂量的增加而增高。在受照剂量为0.494 Gy时，初级精母细胞的辐射敏感性似乎高于精原细胞和精细胞。

Abstract

The frequency of dominant lethal mutation (DLM) in the germ cells of male mice induced by HTO-irradiation was studied. HTO was injected to the male mice at the active concentration of 3.22—31.23×10,2, kBq/g. b. w. which emitted the accumulative doses of 0.073—0.710 Gy within the following 20 days. The results suggested that the frequencies of DLM and post implantation loss induced at spermatids increased with the increasing of the dose absorbed. Primary spermatocytes appeared to be more radiosensitive than spermatognia and spermatids when the germ cells were exposed at 0.494 Gy.

关键词

氚水雄性生殖细胞显性致死突变辐射敏感性

Keywords

Tritiated waterGerm cells of male miceDominant lethal mutationRadiosensitivity

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