Radiation sterilization will induce degradation of col lagen and proteoglycans in the skin and bone grafts. Dose choice of radiation steril ization is decided by the balace of the reliable sterilization to the microorganisms the and tolerable destruction to the graft. The present research supports that 15 kGy is optimal dose to fulfill both the above requirements, provided that skin and bone grafts are prepared under sterile working condition with feasible caution to diminish the initial bioburden as far as possible. Glutaraldehyde pretreatment of skin and bone grafts was proposed for overcoming radiation induced degradation of dermal collagen and bone matrix and it is hopeful for restraining the exaggerated resorption of radiation sterilized AAA bones.