PROLIFERATION ABILITY ON BONE MARROW AND THYMUS CELLS OF RATS TREATED WITH LOW DOSES OF INTERNAL RADIATORS

Zhu Shoupeng; Yang Zhunshan; Xia Fen

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PROLIFERATION ABILITY ON BONE MARROW AND THYMUS CELLS OF RATS TREATED WITH LOW DOSES OF INTERNAL RADIATORS

更新时间：2023-04-23

- PROLIFERATION ABILITY ON BONE MARROW AND THYMUS CELLS OF RATS TREATED WITH LOW DOSES OF INTERNAL RADIATORS
- Journal of Radiation Research and Radiation Processing Vol. 11, Issue 3, Pages: 172-175,171(1993)
- 作者机构：
  
  1.苏州医学院，苏州　215007
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Zhu Shoupeng, Yang Zhunshan, Xia Fen. PROLIFERATION ABILITY ON BONE MARROW AND THYMUS CELLS OF RATS TREATED WITH LOW DOSES OF INTERNAL RADIATORS. [J]. Journal of Radiation Research and Radiation Processing 11(3):172-175,171(1993)
DOI：

Zhu Shoupeng, Yang Zhunshan, Xia Fen. PROLIFERATION ABILITY ON BONE MARROW AND THYMUS CELLS OF RATS TREATED WITH LOW DOSES OF INTERNAL RADIATORS. [J]. Journal of Radiation Research and Radiation Processing 11(3):172-175,171(1993) DOI：

摘要

在放射性裂变产物中，观察到小剂量不同辐射体核素,147,Pm和,134,Cs内辐照对骨髓和胸腺细胞的刺激增殖作用。,147,Pm的体内滞留方程，用最小二乘法拟合为：R（t）=0.199 e,-0.1452t,+ 0.812 e,-0.0008t,，包括快、慢两个不同的滞留半减期，其中快组分T,1,=4.77 d，而慢组分T,2,=866.3 d。,134,Cs的体内滞留方程为：R（t）=18.04 e,-9.3175t,+45.13 e,-0.0423t,，其快组分T,1,=0.07 d，慢组分T,2,= 16.14 d。当大鼠静脉摄入,147,Pm 0.185—0.74 kBq/g或,134,Cs 0.37—1.85 kBq/g后，可使骨髓细胞和胸腺细胞的,3,H-TdR掺入率呈显著增升，表明其DNA合成能力增高，有刺激骨髓与胸腺细胞增殖作用。

Abstract

In this article the dynamic retention of fission products ,134,Cs and ,147,Pm as well as the proliferation ability on cells of bone marrow and thymus of rats were investigated. The retention equation of ,134,Cs was well described by a two-exponential function, that is: R(t)=18.04 e-,9.3175t,+45.13 e-,0.0423t,. There are two retention components, fast and slow. The effective biological T,1/2, were 0.07 and 16.14 days respectively. While the retention equation of ,147,Pm is: R(t)= 0.199e,-0.1452t, +0.812 e,-0.0008t,. Where the fast component T,1, was 4.77 d; and the slow compoment T,2, was 866.3 d. Results show that the proliferation of bone marrow cells and thymus cells were excited with a low dose internal irradiation of ,134,Cs from 0.37 to 1.85 kBq/g and of ,147,Pm from 0.185 to 0.74 kBq/g. It showed that a stimulatory resporse of cell proliferation induced by low doses of ,134,Cs and ,147,Pm has been obser ved.

关键词

小剂量照射内照射147Pm134Cs胸腺细胞骨髓细胞刺激作用

Keywords

Low doseInterna Iradiation147Pm134CsBone marrow cellsThymus cellsStimulatory effect

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