SISTER CHROMATID EXCHANGE IN HUMAN LYMPHOCYTES INDUCED BY IONIZING IRRADIATION AND SUPEROXIDE ANIONS

Luo Liming; Jin Yizun; Lin Nianyun; Zheng Rongliang

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SISTER CHROMATID EXCHANGE IN HUMAN LYMPHOCYTES INDUCED BY IONIZING IRRADIATION AND SUPEROXIDE ANIONS

更新时间：2023-04-23

- SISTER CHROMATID EXCHANGE IN HUMAN LYMPHOCYTES INDUCED BY IONIZING IRRADIATION AND SUPEROXIDE ANIONS
- Journal of Radiation Research and Radiation Processing Vol. 11, Issue 3, Pages: 176-179(1993)
- 作者机构：
  
  1.兰州大学生物系，兰州　730000
  1.上海医科大学放射医学研究所，上海　200032
  1.中国科学院辐射化学开放研究实验室，上海原子核研究所，上海　201800
- 作者简介：
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Luo Liming, Jin Yizun, Lin Nianyun, et al. SISTER CHROMATID EXCHANGE IN HUMAN LYMPHOCYTES INDUCED BY IONIZING IRRADIATION AND SUPEROXIDE ANIONS. [J]. Journal of Radiation Research and Radiation Processing 11(3):176-179(1993)
DOI：

Luo Liming, Jin Yizun, Lin Nianyun, et al. SISTER CHROMATID EXCHANGE IN HUMAN LYMPHOCYTES INDUCED BY IONIZING IRRADIATION AND SUPEROXIDE ANIONS. [J]. Journal of Radiation Research and Radiation Processing 11(3):176-179(1993) DOI：

摘要

用姐妹染色单体交换（SCE）作为指标，研究了,60,Co γ射线辐照及NADH-PMS（吩嗪硫酸甲酯）系统中产生的超氧阴离子自由基（O,2,•-,）对胎儿脐血淋巴细胞染色体的损伤作用，及活性氧清除剂SOD和甘露醇的保护作用。结果显示γ射线及O,2,•-,都能诱发细胞SCE频率显著升高，且存在一定的剂量-效应关系。SOD及甘露醇对O,2,•-,诱发的损伤有明显的保护作用。

Abstract

SCE was studied in human lymphocytes exposed to ,60,Co-γ ray and superoxide radical. Both γ-ray and superoxide radical produced a statistically significant increase in SCE over baseline. Dose-response relationships were observed. But a 2-fold increment of SCE wasn′t reached in both agents. SOD and mannitol have preventive effect on the damage caused by active oxygen species.

关键词

姐妹染色单体交换（SCE）电离辐射超氧阴离子基氧自由基清除剂淋巴细胞

Keywords

Sister chromatid exchangeIonizing irradiationSuperoxide anionsFree radical scavengerLymphocytes

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