THE ADAPTIVE RESPONSE OF MUTAGENESIS INDUCED BY LOW DOSE RADIATION IN MAMMALIAN CELLS

Zhou Pingkun; Sun Wenzhong; Liu Xueying; Zhang Yangpei; Wei Kang

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THE ADAPTIVE RESPONSE OF MUTAGENESIS INDUCED BY LOW DOSE RADIATION IN MAMMALIAN CELLS

更新时间：2023-04-23

- THE ADAPTIVE RESPONSE OF MUTAGENESIS INDUCED BY LOW DOSE RADIATION IN MAMMALIAN CELLS
- Journal of Radiation Research and Radiation Processing Vol. 11, Issue 4, Pages: 237-239,247(1993)
- 作者机构：
  
  1.北京放射医学研究所，北京　100850
- 作者简介：
- 基金信息：
  
  IAEA
- DOI：
  CLC：
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Zhou Pingkun, Sun Wenzhong, Liu Xueying, et al. THE ADAPTIVE RESPONSE OF MUTAGENESIS INDUCED BY LOW DOSE RADIATION IN MAMMALIAN CELLS. [J]. Journal of Radiation Research and Radiation Processing 11(4):237-239,247(1993)
DOI：

Zhou Pingkun, Sun Wenzhong, Liu Xueying, et al. THE ADAPTIVE RESPONSE OF MUTAGENESIS INDUCED BY LOW DOSE RADIATION IN MAMMALIAN CELLS. [J]. Journal of Radiation Research and Radiation Processing 11(4):237-239,247(1993) DOI：

摘要

预先用小剂量γ射线照射小鼠SR-1细胞，然后观察其对随后大剂量γ射线照射诱发细胞hprt基因突变的影响。0.01 Gy小剂量一次预照射，18 h、24 h后能显著降低3 Gy照射诱发SR-1细胞的hprt基因突变频率。细胞每天接受一次0.01 Gy照射，共10 d，累积剂量达0.1 Gy后，6 h就能产生上述效应，并可持续到小剂量刺激后的48 h，hprt基因突变频率下降了30%—40%。

Abstract

The effect of low dose γ-ray pre-exposure on the induction of hprt locus mutations by subsequent high dose challenge in mouse mammary carcinoma SR-1 cells was studied. Pre-exposure of SR-1 cells with 0.01 Gy low dose at 18 h or 24 h before high dose challenging, could significantly decrease the frequency of hprt mutation induced by 3 Gy irradiation. Pre-exposure of cells with 0.01 Gy per day, could result in the above effect at as early as 6 h after the accumulating dose attained 0.1 Gy, the effect lasted at least for 48 h, and the yield of mutations induced by 3 Gy was reduced by 30% to 40%.

关键词

小剂量电离辐射适应性反应hprt基因突变

Keywords

Low dose ionizing radiationAdaptive responseHprt geneMutagenesis

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