STUDY ON DOSE-REPSONSE RELATIONSHIP BETWEEN PRENATAL EXPOSURE TO TRITIATED WATER AND THE DEVELOPMENTAL RETARDATION OF BRAIN IN RATS

Yang Zhiyuan; Guo Yuefeng; Wang Mingming

您当前的位置：

首页 >

文章列表页 >

STUDY ON DOSE-REPSONSE RELATIONSHIP BETWEEN PRENATAL EXPOSURE TO TRITIATED WATER AND THE DEVELOPMENTAL RETARDATION OF BRAIN IN RATS

更新时间：2023-04-23

- STUDY ON DOSE-REPSONSE RELATIONSHIP BETWEEN PRENATAL EXPOSURE TO TRITIATED WATER AND THE DEVELOPMENTAL RETARDATION OF BRAIN IN RATS
- Journal of Radiation Research and Radiation Processing Vol. 11, Issue 4, Pages: 240-243(1993)
- 作者机构：
  
  1.中国辐射防护研究院，太原　030006
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
Yang Zhiyuan, Guo Yuefeng, Wang Mingming. STUDY ON DOSE-REPSONSE RELATIONSHIP BETWEEN PRENATAL EXPOSURE TO TRITIATED WATER AND THE DEVELOPMENTAL RETARDATION OF BRAIN IN RATS. [J]. Journal of Radiation Research and Radiation Processing 11(4):240-243(1993)
DOI：

Yang Zhiyuan, Guo Yuefeng, Wang Mingming. STUDY ON DOSE-REPSONSE RELATIONSHIP BETWEEN PRENATAL EXPOSURE TO TRITIATED WATER AND THE DEVELOPMENTAL RETARDATION OF BRAIN IN RATS. [J]. Journal of Radiation Research and Radiation Processing 11(4):240-243(1993) DOI：

摘要

以脑组织中游离氨基酸含量为指标，观察出生前因氚水照射引起的大鼠脑发育障碍。实验用妊娠11 d的大鼠经腹腔单次注入7.4×10,3,—3.7×10,6,Bq/ml（体水）放射性浓度的氚水。在仔鼠出生后18 d将其开颅取出大脑。取一半脑组织用高效液相色谱（HPLC）测定脑组织中游离氨基酸含量。结果表明：受照仔鼠大脑组织中游离氨基酸含量随照射剂量增加而增多。在仔鼠总吸收剂量为0.0038—1.9 Gy范围内，大脑组织中游离氨基酸含量增加的百分率与剂量对数值之间可拟合成直线回归方程,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650454&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650456&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650455&type=,。

Abstract

The developmental ratardation of brain in rats induced by prental exposure to HTO had observed by measuring the contents of cerebral amino acids. The HTO was injected intraperitoneally at the 11 th day of gestation with concentration of 7.4×10,3,—3.7×10,6, Bq/ml (body water). At 18-day-old the young rats were killed and their brains were saparated from skulls. The brains were used to make biochemical speciments for measuring the contents of amino acids.The results showed that the contents of amino acids increases with the dose increased and the relationship between the precentage of the increased contents of amino acids in brain and logarithm of absorbed doses (D, Gy) give a good fit to liner regression equation ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650457&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650489&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650488&type=, in range of the absorbed doses from 0.0038—1.9 Gy.

关键词

氚水（HTO）氨基酸辐射剂量效应关系大鼠

Keywords

Tritiated water (HTO)Amino acidsPrenatal irradiationDoseresponse relationshipRat

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Influence of electron-beam irradiation on amino acids and protein structure

Changes of myelin in the rat brain after whole-brain irradiation

Study on ultrastructural changes in thyroid gland of rats exposed to pulsed electromagnetic wave

Superhigh dose effects of 6 MeV EB irradiation on Ca²⁺ and Mg²⁺ contents in rat brain

Effect of electromagnetic pulse (EMP) on ultrastructure of pituitary gland in rats

Related Author

No data

Related Institution

Agricultural Products Quality and Safety Risk Assessment Laboratory Ministry of Agriculture and Rural Affaies of the People's Republic of China

Supervision and Testing Center for Edible Fungi Quality, Ministry of Agriculture and Rural Affaies of the People's Republic of China

Institute of Crop Science, Shanghai Academy of Agricultural Sciences

Shanghai SN Irradiation Technology Co., Ltd. Shanghai Academy of Agricultural Sciences

Institute for Agri-food Quality Standards and Technology, Shanghai Academy of Agricultural Sciences

⁰