RADIOPROTECTIVE EFFECTS OF PANAXATROIL ON OPIOID PEPTIDES AND IMMUNE FUNCTIONS IN MALE RATS

Liu Weihong; Gong Shouliang; Li Xiuyi; Li Xinmin; Liu Shusheng

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RADIOPROTECTIVE EFFECTS OF PANAXATROIL ON OPIOID PEPTIDES AND IMMUNE FUNCTIONS IN MALE RATS

更新时间：2023-04-23

- RADIOPROTECTIVE EFFECTS OF PANAXATROIL ON OPIOID PEPTIDES AND IMMUNE FUNCTIONS IN MALE RATS
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 3, Pages: 169-173(1994)
- 作者机构：
  
  1.白求恩医科大学放射生物教研室，长春　130021
- 作者简介：
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Liu Weihong, Gong Shouliang, Li Xiuyi, et al. RADIOPROTECTIVE EFFECTS OF PANAXATROIL ON OPIOID PEPTIDES AND IMMUNE FUNCTIONS IN MALE RATS. [J]. Journal of Radiation Research and Radiation Processing 12(3):169-173(1994)
DOI：

Liu Weihong, Gong Shouliang, Li Xiuyi, et al. RADIOPROTECTIVE EFFECTS OF PANAXATROIL ON OPIOID PEPTIDES AND IMMUNE FUNCTIONS IN MALE RATS. [J]. Journal of Radiation Research and Radiation Processing 12(3):169-173(1994) DOI：

摘要

采用5 Gy X射线全身照射雄性大鼠模型，大鼠于照射前24 h及照射后，每天腹腔注射5 mg/0.2 ml人参三醇组甙，共注射14 d，观察人参三醇组甙对其阿片肽与免疫功能的辐射防护作用。结果表明，照射组下丘脑阿片肽含量及胸腺和脾脏免疫参数均降低；而在照射加人参组下丘脑阿片肽组水平，所有的免疫参数虽降低但却高于照射组。结果提示，人参三醇组甙可减轻下丘脑阿片肽含量及含量接近对照胸腺和脾脏免疫参数的降低，具有辐射防护作用。

Abstract

The present study was designed by ip panaxatroil (5 mg/0.2 ml•d × 14 d) 24 h before and after 5 Gy whole-body X-irradiation in male rats to observe the radioprotective effects of panaxatroil on opioid peptides and immune functions. The results showed that the hypothalamic opioid peptide contents and the immune parameters of thymus and spleen cells all decreased 14 d after irradiation, while hypothalamic opioid peptide contents approached the control level and all immune parameters decreased in irradiation plus panaxatroil group but higher than that in control group. The above results suggest that panaxatroil may alleviate the decrease of hypothalamic opioid peptide contents and immune parameters of thymus and spleen cells, and have radioprotective effects.

关键词

人参三醇组甙辐射防护阿片肽免疫参数

Keywords

PanaxatroilRadioprotectionOpioid peptidesImmune parameters

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