RESTORATIVE EFFECT OF EXOGENOUS RNA ON THE INTESTINAL CRYPTS IN MICE AFTER ABDOMINAL γ-IRRADIATION

Zeng Guiying; Han Shichen; Liu Aiping; Xie Xuejun; Zhou Ynankai

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RESTORATIVE EFFECT OF EXOGENOUS RNA ON THE INTESTINAL CRYPTS IN MICE AFTER ABDOMINAL γ-IRRADIATION

更新时间：2023-04-23

- RESTORATIVE EFFECT OF EXOGENOUS RNA ON THE INTESTINAL CRYPTS IN MICE AFTER ABDOMINAL γ-IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 13, Issue 4, Pages: 233-238(1995)
- 作者机构：
  
  1.第四军医大学防原医学教研室，西安　710032
- 作者简介：
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Zeng Guiying, Han Shichen, Liu Aiping, et al. RESTORATIVE EFFECT OF EXOGENOUS RNA ON THE INTESTINAL CRYPTS IN MICE AFTER ABDOMINAL γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 13(4):233-238(1995)
DOI：

Zeng Guiying, Han Shichen, Liu Aiping, et al. RESTORATIVE EFFECT OF EXOGENOUS RNA ON THE INTESTINAL CRYPTS IN MICE AFTER ABDOMINAL γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 13(4):233-238(1995) DOI：

摘要

BALB/c小鼠接受1040 cGy ,60,Co γ射线腹部照射后，采用不同来源的RNA、不同的注入剂量、途径、时间和次数等因素，研究外源RNA对空肠肠腺存活率的影响。结果表明：（1）不同来源的RNA均可明显提高受照小鼠的肠腺存活率。（2）酵母RNA的注入剂量与肠腺存活率之间呈一钟形曲线，局部肠腔注入的最适剂量为40～60 µg/小鼠，腹腔和肌肉注入时均为80 µg/小鼠。（3）采用从（静脉、腹腔、肌肉和皮下）不同途径注入酵母RNA，均可显著提高受照小鼠的肠腺存活率，其中静脉注入效果最佳。（4）照射后小鼠的肠腺存活率随注入酵母RNA时间的推迟而降低，两者在半对数坐标上呈线性关系。（5）小鼠于照射后6h内1次注入RNA，即可生效，多次注入并不增加其疗效。

Abstract

Our previous investigtion revealed a restorative effect of exogenous nucleic acids on the intestinal crypt in mice after abdominal γ-irradiation. In this article, the factors influencing the restorative effect of exogenous RNA on the intestinal crypt in mice post-irradiation were studied. The results showed that: (a)RNAs from different sources all showed the crypt survival enhancement capability.(b) Bell-shaped curves correlating the crypt survival fraction and RNA doses were obtained, with the optimal doses for different routes of administration estimated.(c) Comparing the different routes of RNA administration, the intravenous injection seemed to be the most effective. (d) An exponential relationship between the crypt survival fraction and the post-irradiation time of RNA administration was found. The earlier the administration, the more effective it was. (e) Administration of RNA merely once within 6 h after irradiation, the increases of crypt survival fraction was statistically significant when compared with that of the irradiated control.

关键词

外源RNA电离辐射肠腺存活率辐射损伤

Keywords

Exogenous RNAIonizing radiationIntestinal crypt survivalRadiation injury

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