PROTECTIVE AND PROMOTING EFFECTS OF FETAL MUSCLE CONDITIONED MEDIUM ON HEMATOPOIESIS IN IRRADIATED MICE

Wei Hulai; Zhao Huishun; Ma Lanfang

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PROTECTIVE AND PROMOTING EFFECTS OF FETAL MUSCLE CONDITIONED MEDIUM ON HEMATOPOIESIS IN IRRADIATED MICE

更新时间：2023-04-23

- PROTECTIVE AND PROMOTING EFFECTS OF FETAL MUSCLE CONDITIONED MEDIUM ON HEMATOPOIESIS IN IRRADIATED MICE
- Journal of Radiation Research and Radiation Processing Vol. 14, Issue 1, Pages: 55-58(1996)
- 作者机构：
  
  1.兰州医学院血液病研究所，兰州　730000
- 作者简介：
- 基金信息：
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Wei Hulai, Zhao Huishun, Ma Lanfang. PROTECTIVE AND PROMOTING EFFECTS OF FETAL MUSCLE CONDITIONED MEDIUM ON HEMATOPOIESIS IN IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 14(1):55-58(1996)
DOI：

Wei Hulai, Zhao Huishun, Ma Lanfang. PROTECTIVE AND PROMOTING EFFECTS OF FETAL MUSCLE CONDITIONED MEDIUM ON HEMATOPOIESIS IN IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 14(1):55-58(1996) DOI：

摘要

观察了人胎肌条件培养液（FMCM）对6.5 Gy ,60,Co亚致死量照射小鼠造血损伤的保护和促恢复作用。结果证明：照射前小鼠腹腔注射FMCM 2.5～5.0 ml/kg·d×5 d，能有效地预防和延缓因辐射所致的造血干细胞（CFU-S）和外周血细胞的降低；照射后给予同样剂量的FMCM，对辐射所致的小鼠外周血细胞的减低有明显的促恢复作用，能显著促进辐射损伤小鼠的髓外造血重建。表明FMCM对照射造成的造血损伤具有良好的保护和治疗作用。

Abstract

The Balb/C mice were whole body irradiated with γ-rays (,60,Co, 6.5 Gy), and given human fetal muscle conditioned medium (FMCM) before and after irradiation, the protective and promoting effects on hematopoiesis in irradiated mice were observed. The results showed that FMCM given I. P (2.5~5.0 ml kg,-1, d,-1,×5 d) before 6.5 Gy whole body γ-irradiation was able to protect the colony forming unite-spleen (CFU-S), and reduce the decreases of red blood cells (RBC)white blood cells (WBC) and hemeglobin (Hb) in peripheral blood; FMCM given after irradiation could effectively promote the hemopoietic reconstruction in spleen and the increases of RBC, WBC and Hb in peripheral blood. The above results suggest that FMCM has good protective and promoting effects on reducing hematopoietic damage caused by irradiation.

关键词

电离辐射造血损伤胎肌条件培养液（FMCM）辐射防护

Keywords

IrradiationHematopoietic damageFetal muscle conditioned medium (FMCM)Radioprotection

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