BONE METABOLISM AND IMMUNOLOGICAL FUNCTION OF SPLENIC AFTER OVARIAN IRRADIATION

Jin Weifang; Wang Hongfu; Zhang Haijun; Huang Hui

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BONE METABOLISM AND IMMUNOLOGICAL FUNCTION OF SPLENIC AFTER OVARIAN IRRADIATION

更新时间：2023-04-23

- BONE METABOLISM AND IMMUNOLOGICAL FUNCTION OF SPLENIC AFTER OVARIAN IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 14, Issue 4, Pages: 239-243(1996)
- 作者机构：
  
  1.上海医科大学放射医学研究所　上海　200032
- 作者简介：
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Jin Weifang, Wang Hongfu, Zhang Haijun, et al. BONE METABOLISM AND IMMUNOLOGICAL FUNCTION OF SPLENIC AFTER OVARIAN IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):239-243(1996)
DOI：

Jin Weifang, Wang Hongfu, Zhang Haijun, et al. BONE METABOLISM AND IMMUNOLOGICAL FUNCTION OF SPLENIC AFTER OVARIAN IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):239-243(1996) DOI：

摘要

雌激素维护骨代谢，并抑制淋巴细胞免疫功能。以50 Gy X射线局部照射大鼠卵巢，造成卵泡闭锁、雌二醇（E,2,）低下，并致尿Ca/cr（钙／肌肝）、HOP/cr（羟脯氨酸／肌肝）和血ALP（碱性磷酸酶）升高，骨小梁数和面积减小，淋巴细胞增殖和分泌IL-2的活性增加。淋巴细胞分泌IL-2的活性与血E,2,水平呈显著负相关，24 h尿Ca量与淋巴细胞分泌IL-2的活性呈显著正相关。表明卵巢电离辐射效应对骨代谢和淋巴细胞免疫功能有明显影响，IL-2在雌激素对骨代谢的影响中可能起介导作用。

Abstract

Estrogen is a factor supporting the equilibrium of bone metabolism and inhibiting the immunological function of lymphocytes. In this paper, the occlusion of ovarian follicle, the reduction of estrodiol secretion, the increase of values of Ca/cr and HOP/cr in urine and ALP in serum, the decrease of MTN (mean trabeculae number) and MTV, (mean trabeculae volume) and the increase of proliferation and secretion of IL-2 in splenic of rats wese observed when their ovaries had been irradiation with X-rays of 50Gy. There was obviouse negative correlation between the IL-2 secretion and the level of estrodiol in serum. It also showed marked positive correlation between the level of calcium in urine and the activity of IL-2 secreted by splenic lymphocytes. It was suggested that the bone metabolism and the immunological function of lymphocytes could be influenced by the ovaries exposed to irradiation. The effect of estrogen on bone metabolism might be mediated by IL-2.

关键词

电离辐射效应卵巢骨代谢淋巴细胞白细胞介素Ⅱ

Keywords

Radiation effectOvaryBone metabolismImmunological functionInterlukin-2

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Shanghai Municipal Center For Diseases Control And Prevention

Institute of Radiation Medicine, Fudan University

Laboratory of bone Metabolism, Radiology Institute of Fudan University

Department of Bone Metabolism, Institute of Radiation Medicine, Fudan University

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