ENHANCED EXPRESSION OF c-fos PROTOONCOGENE IN MOUSE LYMPHOID ORGANS FOLLOWING LOW DOSE RADIATION

Wan Hong; Liu Shuzheng

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ENHANCED EXPRESSION OF c-fos PROTOONCOGENE IN MOUSE LYMPHOID ORGANS FOLLOWING LOW DOSE RADIATION

更新时间：2023-04-23

- ENHANCED EXPRESSION OF c-fos PROTOONCOGENE IN MOUSE LYMPHOID ORGANS FOLLOWING LOW DOSE RADIATION
- Journal of Radiation Research and Radiation Processing Vol. 14, Issue 4, Pages: 244-247(1996)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物重点实验室　长春　130021
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(39270207)
- DOI：
  CLC：
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Wan Hong, Liu Shuzheng. ENHANCED EXPRESSION OF c-fos PROTOONCOGENE IN MOUSE LYMPHOID ORGANS FOLLOWING LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):244-247(1996)
DOI：

Wan Hong, Liu Shuzheng. ENHANCED EXPRESSION OF c-fos PROTOONCOGENE IN MOUSE LYMPHOID ORGANS FOLLOWING LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):244-247(1996) DOI：

摘要

应用原位杂交方法观察75 mGy X射线全身照射后不同时间小鼠胸腺、脾、肠系膜淋巴结c-fos基因mRNA转录水平的变化。结果发现，假照组胸腺，脾、肠系膜淋巴结内巨噬细胞、多突起细胞、部分淋巴细胞（主要为大淋巴细胞）c-fos mRNA有低水平基础表达；75 mGy全身照射后c-fos的转录水平明显增高，胸腺为1 h达峰值，脾脏2 h达峰值，肠系膜淋巴结变化幅度较小，但持续时间较长。胸腺和脾脏阳性细胞12 h基本恢复至假照水平，而淋巴结细胞c-fos至照后12 h仍稍高于对照组。实验结果表明，小剂量电离辐射可使免疫活性细胞c-fos的转录水平上调。

Abstract

In situ hybridization was used to examine the expression of c-fos mRNA in mouse thymus, spleen and lymph node following whole body irradiation(WBI) with 75mGy X-rays. The results showed that the basal expression of c-fos mRNA in macrophages, interdigitating cells and some large lymphocytes of thymus, spleen and mesenteric lymph node was markedly enhanced after WBI with 75mGy X-rays. The expression of c-fos mRNA in the thymus and spleen reached its peak 1 h and 2 h after irradiation respectively and both returned to the sham-irradiated level 12 h after irradiation. However, the increase in expression of c-fos mRNA in the lymph node was not so marked but lingered longer after irradiation. The implications of these findings were briefly discussed in connection with our previous data.

关键词

小剂量照射c-fos转录水平原位杂交

Keywords

Low dose radiationProtooncogenec-fosIn situ hybridization

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Department of Radiation Biology, Norman Bethune University of Medical Sciences

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