IMPLICATION OF MORPHOMETRIC CHANGES OF AgNORs IN NEOPLASTIC TRANSFORMATION INDUCED BY γ-IRRADIATION

Fan Feiyue; Cao Zhenshan; Yang Suxia; Li Yu; Zhou Shuzhen; Tu Kaicheng; Liu Guolian

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IMPLICATION OF MORPHOMETRIC CHANGES OF AgNORs IN NEOPLASTIC TRANSFORMATION INDUCED BY γ-IRRADIATION

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- IMPLICATION OF MORPHOMETRIC CHANGES OF AgNORs IN NEOPLASTIC TRANSFORMATION INDUCED BY γ-IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 14, Issue 4, Pages: 248-251(1996)
- 作者机构：
  
  1.北京放射医学研究所　北京　100850
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Fan Feiyue, Cao Zhenshan, Yang Suxia, et al. IMPLICATION OF MORPHOMETRIC CHANGES OF AgNORs IN NEOPLASTIC TRANSFORMATION INDUCED BY γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):248-251(1996)
DOI：

Fan Feiyue, Cao Zhenshan, Yang Suxia, et al. IMPLICATION OF MORPHOMETRIC CHANGES OF AgNORs IN NEOPLASTIC TRANSFORMATION INDUCED BY γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):248-251(1996) DOI：

摘要

应用形态计量学手段，对电离辐射体外诱发人胚肺细胞恶性转化过程中，细胞核内AgNORs颗粒数量、大小及细胞核部分形态计量学参数，随辐射剂量改变的规律进行了研究。接受0.25～5 Gy,60,Co γ照射后第五代的人胚肺细胞核内AgNORs颗粒数量明显增加（P,<,0.05）,而且随着照射剂量的加大呈现逐渐增加的变化的趋势；AgNORs颗粒面积、周长、等效直径等形态计量学参数亦发生明显改变。这些研究结果表明，辐射诱发细胞恶性转化过程中，细胞核内AgNORs颗粒数量的改变，可望用于定量地研究辐射体外诱发细胞恶性转化的剂量效应关系，做为观察细胞恶性转化程度的指标。

Abstract

AgNORs (argyrophilic proteins associated nucleolar organizer regions) has been used to identify whether the cells are malignant or not in the cancer research. It was studied by means of morphometerology, in this report, that changes of AgNORs counting and some morphometric parameters of human embryo lung cell line (HEL-9402) appeared significantly after the HEL-9402 was irradiated by ,60,Co γ-ray. The change character of AgNORs number showed a tendency of increasing gradually with increase of irradiation doses. The implication of changes of AgNORs' area, perimeter and equivalent diameter is not sure although they changed obviously, because they were influenced by the changes of cell nuclei. In conclusion, AgNORs counting may be used to study the relationship between effects and doses during cell neoplastic transformation induced by radiation and expected to become a parameter of identifying malignant degree of transformed cells.

关键词

γ辐射AgNORs形态计量学

Keywords

γ-irradiationAgNORsMorphometerology

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