CHROMOSOME ABERRATION AND SATELLITE ASSOCIATION OF HUMAN BLOOD CULTURES BY <sup>60</sup>Coγ-RAY IRRADIATION IN VITRO

Liu Jinwen; Cheng Guodong; Zhang Rulin; Yao Yanyu

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CHROMOSOME ABERRATION AND SATELLITE ASSOCIATION OF HUMAN BLOOD CULTURES BY ⁶⁰Coγ-RAY IRRADIATION IN VITRO

更新时间：2023-04-26

- CHROMOSOME ABERRATION AND SATELLITE ASSOCIATION OF HUMAN BLOOD CULTURES BY ⁶⁰Coγ-RAY IRRADIATION IN VITRO
- Journal of Radiation Research and Radiation Processing Vol. 3, Issue 3, Pages: 31-36(1985)
- 作者机构：
  
  1.河北省放射医学研究所
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Liu Jinwen, Cheng Guodong, Zhang Rulin, et al. CHROMOSOME ABERRATION AND SATELLITE ASSOCIATION OF HUMAN BLOOD CULTURES BY ⁶⁰Coγ-RAY IRRADIATION IN VITRO. [J]. Journal of Radiation Research and Radiation Processing 3(3):31-36(1985)
DOI：

Liu Jinwen, Cheng Guodong, Zhang Rulin, et al. CHROMOSOME ABERRATION AND SATELLITE ASSOCIATION OF HUMAN BLOOD CULTURES BY ⁶⁰Coγ-RAY IRRADIATION IN VITRO. [J]. Journal of Radiation Research and Radiation Processing 3(3):31-36(1985) DOI：

摘要

本文以两种不同剂量（0.5和1.0 Gy）照射外周血，作了三个不同时间的培养（51、72、96小时），用BudR-Giemsa标记染色体，观察细胞周期变化、姊妹染色单体交换（SCE）率、染色体畸变和随体联合等。结果表明受照后细胞分裂周期有些变化；SCE率变化不大，与培养时间和剂量都无明显关系；双着丝染粒色体畸变与培养时间呈负相关，与剂量呈正相关；随体联合SA,c,和DG,c,指标都随剂量增加而降低，随体联合的形式C/T比值变化不大，尚符合随机分配的遗传基本原则。

Abstract

The change of cell division cycle, the sister-chromatid exchange frequency, chromosome aberration and satellite association are studied by using the BudR-Giemsa Labeling chromosomes. They are carried out after radiation of human peripheral blood in two different doses (0.5 and 1.0 Gy)under the condition of three continued culture times (51, 71 and 96 hr).,The results show that the cell division cycle is apparently changed, a few changes of SCE frequency have not bearing on both culture time and dose, the chromosome aberration has negative correlation with the culture time but positive correlation with dose, the SAc and DGc indexes of the satellite associations are decreased with the dose increase, the satellite association type ratio, C/T is not changed greatly corresponding to the random allocation of genetic basic principle.

关键词

随体联合染色体畸变BudR-Giemsa标记染色体姊妹染色单体交换

Keywords

Satellite associationChromosome aberrationBudR-Giemsa labeling chromosomeSister chromatid exchange

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School of Radiation Medicine and Public Health, Suzhou University

Institute of Radiation Medicine, Academy of Military Medical Sciences

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Department of Toxicology, BeiJing Medical University

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CHROMOSOME ABERRATION AND SATELLITE ASSOCIATION OF HUMAN BLOOD CULTURES BY 60Coγ-RAY IRRADIATION IN VITRO

DOI：

摘要

Abstract

关键词

Keywords

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CHROMOSOME ABERRATION AND SATELLITE ASSOCIATION OF HUMAN BLOOD CULTURES BY ⁶⁰Coγ-RAY IRRADIATION IN VITRO